Cadmium inhalation and male reproductive toxicity

Journal Article · Mon Jan 01 00:00:00 EST 1990 · Reviews of Environmental Contamination and Toxicology; (USA)

DOI:https://doi.org/10.1007/978-1-4612-3368-8_1· OSTI ID:6983237

Ragan, H A; Mast, T J ^[1]

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1. Battelle Pacific Northwest Laboratories, Richland, WA (USA)

Cadmium is a highly toxic element that is cumulative and has a long biological half-life in mammals. The severe toxicity of cadmium in man has been known for more than 100 years. Despite the knowledge that cadmium is toxic, only 20 human cases of poisoning via ingestion were recorded prior to 1941, whereas in the ensuing five-year period more than 680 cases of cadmium poisonings from accidental oral ingestion of this metal were documented. Some of the recorded effects of exposure to cadmium in laboratory animals include renal tubular damage, placental and testicular necrosis, structural and functional liver damage, osteomalacia, testicular tumors, teratogenic malformations, anemia, hypertension, pulmonary edema, chronic pulmonary emphysema, and induced deficiencies of iron, copper, and zinc. Some of these effects have also been observed in human after accidental exposures to cadmium oxide fumes and are characteristic of the syndrome described in Japan as Itai Itai disease in which ingestion of cadmium is the inciting chemical.134 references.

• OSTI ID: 6983237
• Journal Information: Reviews of Environmental Contamination and Toxicology; (USA), Vol. 114; ISSN 0179-5953
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
CADMIUM
TOXICITY
SPERMATOZOA
SENSITIVITY
ENVIRONMENTAL EXPOSURE
INHALATION
KIDNEYS
LIVER
MAN
REVIEWS
TESTES
ANIMALS
BODY
DIGESTIVE SYSTEM
DOCUMENT TYPES
ELEMENTS
GAMETES
GERM CELLS
GLANDS
GONADS
INTAKE
MALE GENITALS
MAMMALS
METALS
ORGANS
PRIMATES
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology