Mass spectrometry with direct supercritical fluid injection

Journal Article · Thu Dec 01 00:00:00 EST 1983 · Anal. Chem.; (United States)

DOI:https://doi.org/10.1021/ac00264a016· OSTI ID:6972431

Smith, R D; Udseth, H R

Direct fluid injection mass spectrometry utilizes supercritical fluids for solvation and transfer of materials to a mass spectrometer chemical ionization (CI) source. Available data suggest that any material soluble in a supercritical fluid is transferred efficiently to the ionization region. Mass spectra are presented for mycotoxins of the trichothecene group obtained by use of supercritical carbon dioxide with isobutane as the CI reagent gas. Direct fluid injection MS/MS is also illustrated for major ions in the isobutane chemical ionization of T-2 toxin. The effect of pressure and temperature upon solubility in supercritical fluids is described and illustrated for diacetoxyscirpenol. A potential method is also demonstrated for ''on-line fractionation'' during MS analysis using pressure to control supercritical fluid solubility. Mass spectra are also presented for polar compounds, using supercritical ammonia, and the extension to complex mixtures is described. The fundamental basis and experimental requirements of the direct fluid injection process are discussed. 1 figure, 11 tables.

• Research Organization: Pacific Northwest Lab., Richland, WA
• DOE Contract Number: AC06-76RL01830
• OSTI ID: 6972431
• Journal Information: Anal. Chem.; (United States), Vol. 55:14
• Country of Publication: United States
• Language: English

Related Subjects

37 INORGANIC
ORGANIC
PHYSICAL AND ANALYTICAL CHEMISTRY
AMINES
MASS SPECTRA
CHLORINATED AROMATIC HYDROCARBONS
COAL LIQUIDS
MASS SPECTROMETERS
EQUIPMENT INTERFACES
FLUID INJECTION PROCESSES
SUPERCRITICAL FLUID CHROMATOGRAPHY
TOXINS
2-METHYLPROPANE
AMMONIA
CALIBRATION
CARBON DIOXIDE
CONDENSED AROMATICS
CRITICAL PRESSURE
CRITICAL TEMPERATURE
EXPERIMENTAL DATA
FEASIBILITY STUDIES
FLOW RATE
GASES
HIGH PRESSURE
HIGH TEMPERATURE
MEDIUM PRESSURE
MEDIUM TEMPERATURE
PRESSURE DEPENDENCE
QUALITATIVE CHEMICAL ANALYSIS
REAGENTS
SOLVATION
SOLVENT PROPERTIES
TEMPERATURE DEPENDENCE
TIME DEPENDENCE
ALKANES
ANTIGENS
AROMATICS
CARBON COMPOUNDS
CARBON OXIDES
CHALCOGENIDES
CHEMICAL ANALYSIS
CHROMATOGRAPHY
DATA
FLUIDS
HALOGENATED AROMATIC HYDROCARBONS
HYDRIDES
HYDROCARBONS
HYDROGEN COMPOUNDS
INFORMATION
LIQUIDS
MATERIALS
MEASURING INSTRUMENTS
NITROGEN COMPOUNDS
NITROGEN HYDRIDES
NUMERICAL DATA
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
OXIDES
OXYGEN COMPOUNDS
PHYSICAL PROPERTIES
SEPARATION PROCESSES
SPECTRA
SPECTROMETERS
THERMODYNAMIC PROPERTIES
TOXIC MATERIALS
TRANSITION TEMPERATURE
400104* - Spectral Procedures- (-1987)