Mass spectrometry with direct supercritical fluid injection

Journal Article · Thu Dec 01 04:00:00 EST 1983 · Anal. Chem.; (United States)

DOI:https://doi.org/10.1021/ac00264a016· OSTI ID:6119496

Smith, R D; Udseth, H R

Direct fluid injection mass spectrometry utilizes supercritical fluids for solvation and transfer of materials to a mass spectrometer chemical ionization (CI) source. Available data suggest that any material soluble in a supercritical fluid is transferred efficiently to the ionization region. Mass spectra are presented for mycotoxins of the trichothecene group obtained by use of supercritical carbon dioxide with isobutane as the CI reagent gas. Direct fluid injection MS/MS is also illustrated for major ions in the isobutane chemical ionization of T-2 toxin. The effect of pressure and temperature upon solubility in supercritical fluids is described and illustrated for diacetoxycirpenol. A potential method is also demonstrated for on-line fraction during MS analysis using pressure to control supercritical fluid solubility. Mass spectra are also presented for polar compounds, using supercritical ammonia, and the extension to complex mixtures is described. The fundamental basis and experimental requirements of the direct fluid injection process are discussed. 34 references, 11 figures, 1 table.

• Research Organization: Pacific Northwest Lab., Richland, WA
• DOE Contract Number: AC06-76RL01830
• OSTI ID: 6119496
• Journal Information: Anal. Chem.; (United States), Journal Name: Anal. Chem.; (United States) Vol. 55:14; ISSN ANCHA
• Country of Publication: United States
• Language: English

Related Subjects

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
400104* -- Spectral Procedures-- (-1987)
ALCOHOLS
ALKANES
AROMATICS
BIPHENYL
BUTANOLS
CHROMATOGRAPHY
DATA
DISEASES
EXPERIMENTAL DATA
FLUID INJECTION PROCESSES
FUNGAL DISEASES
HIGH PRESSURE
HYDROCARBONS
HYDROXY COMPOUNDS
INFECTIOUS DISEASES
INFORMATION
ION SOURCES
MASS SPECTROSCOPY
MEDIUM TEMPERATURE
METHYLENE CHLORIDE
MYCOSES
NUMERICAL DATA
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
PENTANE
REAGENTS
SEPARATION PROCESSES
SPECTROSCOPY
SUPERCRITICAL FLUID CHROMATOGRAPHY