Mass spectrometry with direct supercritical fluid injection

Journal Article · Wed Nov 30 23:00:00 EST 1983 · Anal. Chem.; (United States)

DOI:https://doi.org/10.1021/ac00264a016· OSTI ID:6972431

Smith, R D; Udseth, H R

Direct fluid injection mass spectrometry utilizes supercritical fluids for solvation and transfer of materials to a mass spectrometer chemical ionization (CI) source. Available data suggest that any material soluble in a supercritical fluid is transferred efficiently to the ionization region. Mass spectra are presented for mycotoxins of the trichothecene group obtained by use of supercritical carbon dioxide with isobutane as the CI reagent gas. Direct fluid injection MS/MS is also illustrated for major ions in the isobutane chemical ionization of T-2 toxin. The effect of pressure and temperature upon solubility in supercritical fluids is described and illustrated for diacetoxyscirpenol. A potential method is also demonstrated for ''on-line fractionation'' during MS analysis using pressure to control supercritical fluid solubility. Mass spectra are also presented for polar compounds, using supercritical ammonia, and the extension to complex mixtures is described. The fundamental basis and experimental requirements of the direct fluid injection process are discussed. 1 figure, 11 tables.

• Research Organization: Pacific Northwest Lab., Richland, WA
• DOE Contract Number: AC06-76RL01830
• OSTI ID: 6972431
• Journal Information: Anal. Chem.; (United States), Journal Name: Anal. Chem.; (United States) Vol. 55:14; ISSN ANCHA
• Country of Publication: United States
• Language: English

Related Subjects

2-METHYLPROPANE
37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
400104* -- Spectral Procedures-- (-1987)
ALKANES
AMINES
AMMONIA
ANTIGENS
AROMATICS
CALIBRATION
CARBON COMPOUNDS
CARBON DIOXIDE
CARBON OXIDES
CHALCOGENIDES
CHEMICAL ANALYSIS
CHLORINATED AROMATIC HYDROCARBONS
CHROMATOGRAPHY
COAL LIQUIDS
CONDENSED AROMATICS
CRITICAL PRESSURE
CRITICAL TEMPERATURE
DATA
EQUIPMENT INTERFACES
EXPERIMENTAL DATA
FEASIBILITY STUDIES
FLOW RATE
FLUID INJECTION PROCESSES
FLUIDS
GASES
HALOGENATED AROMATIC HYDROCARBONS
HIGH PRESSURE
HIGH TEMPERATURE
HYDRIDES
HYDROCARBONS
HYDROGEN COMPOUNDS
INFORMATION
LIQUIDS
MASS SPECTRA
MASS SPECTROMETERS
MATERIALS
MEASURING INSTRUMENTS
MEDIUM PRESSURE
MEDIUM TEMPERATURE
NITROGEN COMPOUNDS
NITROGEN HYDRIDES
NUMERICAL DATA
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
OXIDES
OXYGEN COMPOUNDS
PHYSICAL PROPERTIES
PRESSURE DEPENDENCE
QUALITATIVE CHEMICAL ANALYSIS
REAGENTS
SEPARATION PROCESSES
SOLVATION
SOLVENT PROPERTIES
SPECTRA
SPECTROMETERS
SUPERCRITICAL FLUID CHROMATOGRAPHY
TEMPERATURE DEPENDENCE
THERMODYNAMIC PROPERTIES
TIME DEPENDENCE
TOXIC MATERIALS
TOXINS
TRANSITION TEMPERATURE