Differences in irradiation susceptibility and turnover between mucosal and connective tissue-type mast cells of mice

Journal Article · Wed Aug 01 00:00:00 EDT 1990 · Experimental Hematology (Lawrence, Kansas); (USA)

OSTI ID:6790381

Fukuzumi, T; Waki, N; Kanakura, Y; Nagoshi, J; Hirota, S; Yoshikawa, K; Kitamura, Y ^[1]

---

1. Osaka Univ. Medical School (Japan)

Although precursors of mast cells are derived from the bone marrow, phenotypes of mast cells are influenced by the tissues in which final differentiation occurs. Connective tissue-type mast cells (CTMC) and mucosal mast cells (MMC) are different in morphological, biochemical, immunological, and functional criteria. The purpose of the present study was to obtain information about the differentiation process of MMC. First, we compared changes in irradiation susceptibility in mice during the differentiation process of CTMC and MMC. The decrease in irradiation susceptibility was remarkable in the CTMC differentiation process, but it was moderate in that of MMC. Some morphologically identifiable CTMC in the peritoneal cavity had proliferative potential and were highly radioresistant, whereas such a radioresistant population of MMC was not detectable in the gastric mucosa. Second, we estimated the turnover of CTMC and MMC by determining the proportion of mast cells that were labeled with continuously administered bromodeoxyuridine. The turnover of MMC was significantly faster than that of CTMC. The absence of the radioresistant mast cell population in the gastric mucosa appeared to be related to the short life span of MMC.

• OSTI ID: 6790381
• Journal Information: Experimental Hematology (Lawrence, Kansas); (USA), Vol. 18:7; ISSN 0301-472X
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
MAST CELLS
RADIOSENSITIVITY
ANIMAL TISSUES
BONE MARROW
BUDR
CELL DIFFERENTIATION
DNA
DOSE-RESPONSE RELATIONSHIPS
MICE
MUCOUS MEMBRANES
PERITONEUM
PHENOTYPE
X RADIATION
ANIMAL CELLS
ANIMALS
ANTIMETABOLITES
AZINES
BODY
BROMOURACILS
CONNECTIVE TISSUE CELLS
DRUGS
ELECTROMAGNETIC RADIATION
HEMATOPOIETIC SYSTEM
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
IONIZING RADIATIONS
MAMMALS
MEMBRANES
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC BROMINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PYRIMIDINES
RADIATIONS
RIBOSIDES
RODENTS
SEROUS MEMBRANES
SOMATIC CELLS
TISSUES
URACILS
VERTEBRATES
560120* - Radiation Effects on Biochemicals
Cells
& Tissue Culture