Cyctotoxicities of mitomycin C and x rays to aerobic and hypoxic cells in vitro

Journal Article · Fri Jan 01 00:00:00 EST 1982 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

DOI:https://doi.org/10.1016/0360-3016(82)90173-0· OSTI ID:6714938

Rockwell, S

Aerobic and hypoxic EMT6 mouse mammary tumor cells in exponential growth in vitro were used to study cell survival after treatment with radiation (250k V X rays) and mitomycin C in various combinations. The cytotoxicities of the two agents were found to be additive as judged by comparing dose-response curves for each agent alone with survival curves after combination therapy and by isobologram analysis. The cytotoxicities resulting from combination treatments were found to be independent of the sequence of the treatments or the interval between treatments.

• OSTI ID: 6714938
• Journal Information: Int. J. Radiat. Oncol., Biol. Phys.; (United States), Vol. 8:6
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
CELL KILLING
RADIOINDUCTION
MITOMYCIN
SYNERGISM
TUMOR CELLS
BIOLOGICAL RADIATION EFFECTS
X RADIATION
ANOXIA
IN VITRO
MICE
SURVIVAL CURVES
TOXICITY
ANIMAL CELLS
ANIMALS
ANTI-INFECTIVE AGENTS
ANTIBIOTICS
ANTIMITOTIC DRUGS
ANTINEOPLASTIC DRUGS
BIOLOGICAL EFFECTS
DRUGS
ELECTROMAGNETIC RADIATION
IONIZING RADIATIONS
MAMMALS
RADIATION EFFECTS
RADIATIONS
RODENTS
VERTEBRATES
560121* - Radiation Effects on Cells- External Source- (-1987)