Combination therapy with radiation and mitomycin C: preliminary results with EMT6 tumor cells in vitro and in vivo
Conference
·
· Int. J. Radiat. Oncol., Biol. Phys.; (United States)
OSTI ID:5340081
EMT6 tumor cells in vitro and in vivo were used to examine the cytoxicity and metabolism of mitomycin C, a bioreductive alkylating agent, and to study the use of this drug in combination with radiation. Mitomycin C was active against both aerobic and hypoxic cells in vitro. The drug did not alter the D/sub 0/'s of the radiation dose-response curves of aerated or hypoxic cells when present during irradiation in vitro or in vivo. Preliminary experiments suggested that mitomycin C may be preferentially metabolized by and toxic to chronically hypoxic cells in vitro. In vivo, mitomycin C reached and was toxic to the cells of solid tumors, including some hypoxic tumor cells.
- Research Organization:
- Yale Univ. School of Medicine, New Haven, CT
- OSTI ID:
- 5340081
- Journal Information:
- Int. J. Radiat. Oncol., Biol. Phys.; (United States), Vol. 5:9; Conference: Conference on combined modalities: chemotherapy/radiotherapy. Part 2, Hilton Head Island, SC, USA, 15 Nov 1978
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
62 RADIOLOGY AND NUCLEAR MEDICINE
MICE
BIOLOGICAL RADIATION EFFECTS
MITOMYCIN
RADIOSENSITIVITY EFFECTS
TOXICITY
TUMOR CELLS
X RADIATION
ANOXIA
DOSE-RESPONSE RELATIONSHIPS
DOSES
EXPERIMENTAL DATA
IN VITRO
IN VIVO
ISOLATED VALUES
METABOLISM
RESPONSE MODIFYING FACTORS
SURVIVAL CURVES
WHOLE-BODY IRRADIATION
ANIMAL CELLS
ANIMALS
ANTIBIOTICS
ANTIMITOTIC DRUGS
BIOLOGICAL EFFECTS
DATA
DATA FORMS
DRUGS
ELECTROMAGNETIC RADIATION
EXTERNAL IRRADIATION
INFORMATION
IONIZING RADIATIONS
IRRADIATION
MAMMALS
NUMERICAL DATA
RADIATION EFFECTS
RADIATIONS
RODENTS
VERTEBRATES
560121* - Radiation Effects on Cells- External Source- (-1987)
560152 - Radiation Effects on Animals- Animals
550603 - Medicine- External Radiation in Therapy- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
MICE
BIOLOGICAL RADIATION EFFECTS
MITOMYCIN
RADIOSENSITIVITY EFFECTS
TOXICITY
TUMOR CELLS
X RADIATION
ANOXIA
DOSE-RESPONSE RELATIONSHIPS
DOSES
EXPERIMENTAL DATA
IN VITRO
IN VIVO
ISOLATED VALUES
METABOLISM
RESPONSE MODIFYING FACTORS
SURVIVAL CURVES
WHOLE-BODY IRRADIATION
ANIMAL CELLS
ANIMALS
ANTIBIOTICS
ANTIMITOTIC DRUGS
BIOLOGICAL EFFECTS
DATA
DATA FORMS
DRUGS
ELECTROMAGNETIC RADIATION
EXTERNAL IRRADIATION
INFORMATION
IONIZING RADIATIONS
IRRADIATION
MAMMALS
NUMERICAL DATA
RADIATION EFFECTS
RADIATIONS
RODENTS
VERTEBRATES
560121* - Radiation Effects on Cells- External Source- (-1987)
560152 - Radiation Effects on Animals- Animals
550603 - Medicine- External Radiation in Therapy- (1980-)