Combination therapy with radiation and mitomycin C: preliminary results with EMT6 tumor cells in vitro and in vivo
Conference
·
· Int. J. Radiat. Oncol., Biol. Phys.; (United States)
OSTI ID:5340081
EMT6 tumor cells in vitro and in vivo were used to examine the cytoxicity and metabolism of mitomycin C, a bioreductive alkylating agent, and to study the use of this drug in combination with radiation. Mitomycin C was active against both aerobic and hypoxic cells in vitro. The drug did not alter the D/sub 0/'s of the radiation dose-response curves of aerated or hypoxic cells when present during irradiation in vitro or in vivo. Preliminary experiments suggested that mitomycin C may be preferentially metabolized by and toxic to chronically hypoxic cells in vitro. In vivo, mitomycin C reached and was toxic to the cells of solid tumors, including some hypoxic tumor cells.
- Research Organization:
- Yale Univ. School of Medicine, New Haven, CT
- OSTI ID:
- 5340081
- Journal Information:
- Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 5:9; ISSN IOBPD
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550603 -- Medicine-- External Radiation in Therapy-- (1980-)
560121* -- Radiation Effects on Cells-- External Source-- (-1987)
560152 -- Radiation Effects on Animals-- Animals
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
ANOXIA
ANTIBIOTICS
ANTIMITOTIC DRUGS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
DATA
DATA FORMS
DOSE-RESPONSE RELATIONSHIPS
DOSES
DRUGS
ELECTROMAGNETIC RADIATION
EXPERIMENTAL DATA
EXTERNAL IRRADIATION
IN VITRO
IN VIVO
INFORMATION
IONIZING RADIATIONS
IRRADIATION
ISOLATED VALUES
MAMMALS
METABOLISM
MICE
MITOMYCIN
NUMERICAL DATA
RADIATION EFFECTS
RADIATIONS
RADIOSENSITIVITY EFFECTS
RESPONSE MODIFYING FACTORS
RODENTS
SURVIVAL CURVES
TOXICITY
TUMOR CELLS
VERTEBRATES
WHOLE-BODY IRRADIATION
X RADIATION
560121* -- Radiation Effects on Cells-- External Source-- (-1987)
560152 -- Radiation Effects on Animals-- Animals
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
ANOXIA
ANTIBIOTICS
ANTIMITOTIC DRUGS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
DATA
DATA FORMS
DOSE-RESPONSE RELATIONSHIPS
DOSES
DRUGS
ELECTROMAGNETIC RADIATION
EXPERIMENTAL DATA
EXTERNAL IRRADIATION
IN VITRO
IN VIVO
INFORMATION
IONIZING RADIATIONS
IRRADIATION
ISOLATED VALUES
MAMMALS
METABOLISM
MICE
MITOMYCIN
NUMERICAL DATA
RADIATION EFFECTS
RADIATIONS
RADIOSENSITIVITY EFFECTS
RESPONSE MODIFYING FACTORS
RODENTS
SURVIVAL CURVES
TOXICITY
TUMOR CELLS
VERTEBRATES
WHOLE-BODY IRRADIATION
X RADIATION