Combination therapy with misonidazole and mitomycin C: lack of chemosensitization of EMT6 tumor cells in vivo or in vitro
Journal Article
·
· Int. J. Radiat. Oncol., Biol. Phys.; (United States)
The effect of the nitroimidazole misonidazole on the cytotoxicity of mitomycin C was examined using EMT6 Rw tumors in mice and EMT6 cells in culture. In contrast to reports by others using a different tumor system, the authors were unable to detect any significant increase of mitomycin cytotoxicity by misonidazole in vivo using tumor cell survival or host toxicity endpoints. Studies with cells in vitro provided no evidence for marked chemosensitization of either hypoxic or aerobic cells.
- Research Organization:
- Yale Univ. School of Medicine, New Haven, CT
- OSTI ID:
- 6166981
- Journal Information:
- Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 10:9; ISSN IOBPD
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560121* -- Radiation Effects on Cells-- External Source-- (-1987)
560152 -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANOXIA
ANTI-INFECTIVE AGENTS
ANTIBIOTICS
ANTIMITOTIC DRUGS
ANTINEOPLASTIC DRUGS
AZOLES
DOSE-RESPONSE RELATIONSHIPS
DRUGS
HETEROCYCLIC COMPOUNDS
IMIDAZOLES
IN VITRO
IN VIVO
MISONIDAZOLE
MITOMYCIN
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
RADIOSENSITIVITY EFFECTS
RADIOSENSITIZERS
TOXICITY
TUMOR CELLS
560152 -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANOXIA
ANTI-INFECTIVE AGENTS
ANTIBIOTICS
ANTIMITOTIC DRUGS
ANTINEOPLASTIC DRUGS
AZOLES
DOSE-RESPONSE RELATIONSHIPS
DRUGS
HETEROCYCLIC COMPOUNDS
IMIDAZOLES
IN VITRO
IN VIVO
MISONIDAZOLE
MITOMYCIN
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
RADIOSENSITIVITY EFFECTS
RADIOSENSITIZERS
TOXICITY
TUMOR CELLS