Combination therapy with misonidazole and mitomycin C: lack of chemosensitization of EMT6 tumor cells in vivo or in vitro

Journal Article · Sat Sep 01 00:00:00 EDT 1984 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

DOI:https://doi.org/10.1016/0360-3016(84)90517-0· OSTI ID:6166981

Rockwell, S

The effect of the nitroimidazole misonidazole on the cytotoxicity of mitomycin C was examined using EMT6 Rw tumors in mice and EMT6 cells in culture. In contrast to reports by others using a different tumor system, the authors were unable to detect any significant increase of mitomycin cytotoxicity by misonidazole in vivo using tumor cell survival or host toxicity endpoints. Studies with cells in vitro provided no evidence for marked chemosensitization of either hypoxic or aerobic cells.

• Research Organization: Yale Univ. School of Medicine, New Haven, CT
• OSTI ID: 6166981
• Journal Information: Int. J. Radiat. Oncol., Biol. Phys.; (United States), Vol. 10:9
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
MISONIDAZOLE
RADIOSENSITIVITY EFFECTS
MITOMYCIN
TOXICITY
ANOXIA
DOSE-RESPONSE RELATIONSHIPS
IN VITRO
IN VIVO
TUMOR CELLS
ANIMAL CELLS
ANTI-INFECTIVE AGENTS
ANTIBIOTICS
ANTIMITOTIC DRUGS
ANTINEOPLASTIC DRUGS
AZOLES
DRUGS
HETEROCYCLIC COMPOUNDS
IMIDAZOLES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
RADIOSENSITIZERS
560121* - Radiation Effects on Cells- External Source- (-1987)
560152 - Radiation Effects on Animals- Animals