Re-evaluation of split-course technique for squamous cell carcinoma of the head and neck
Therapeutic results of split-course vs. continuous-course external beam irradiation were analyzed retrospectively in 468 consecutive patients with squamous cell carcinoma of the oral cavity, oropharynx, nasopharynx, hypopharynx, and supraglottic larynx who were treated with curative intent at the University of Florida between September 1964 and August 1976. 214 patients received split-course treatment and 254 were treated by the continuous-course method. Except for the planned 14 to 16 day interruption after 2820 to 3000 rad in the split-course group, the techniques and total doses of irradiation did not differ. For each stage of disease, patients who received continuous-course irradiation had approximately 10% higher 5-year survival rates than patients who were treated by the split-course technique. The rate of development of late radiation complications was similar for the 2 treatment techniques. Routine use of the split-course technique has been discontinued since the dose required to compensate for the rest interval is unknown.
- Research Organization:
- Univ. of Florida, Gainesville
- OSTI ID:
- 6674234
- Journal Information:
- Int. J. Radiat. Oncol., Biol. Phys.; (United States), Vol. 6:12
- Country of Publication:
- United States
- Language:
- English
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62 RADIOLOGY AND NUCLEAR MEDICINE
BONE TISSUES
DELAYED RADIATION EFFECTS
FRACTIONATED IRRADIATION
COMPARATIVE EVALUATIONS
NECROSIS
RADIOINDUCTION
ORAL CAVITY
PHARYNX
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SIDE EFFECTS
CARCINOMAS
COBALT 60
GAMMA RADIATION
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MEV RANGE 01-10
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RADIUM
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ALKALINE EARTH METALS
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BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BODY AREAS
COBALT ISOTOPES
CONNECTIVE TISSUE
DIGESTIVE SYSTEM
DISEASES
ELECTROMAGNETIC RADIATION
ELEMENTARY PARTICLES
ELEMENTS
ENERGY RANGE
IMPLANTS
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IONIZING RADIATIONS
IRRADIATION
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MASSLESS PARTICLES
MEDICINE
METALS
MEV RANGE
MINUTES LIVING RADIOISOTOPES
NEOPLASMS
NUCLEAR MEDICINE
NUCLEI
ODD-ODD NUCLEI
ORGANS
PATHOLOGICAL CHANGES
RADIATION EFFECTS
RADIATION SOURCES
RADIATIONS
RADIOISOTOPES
RADIOLOGY
RESPIRATORY SYSTEM
THERAPY
TISSUES
YEARS LIVING RADIOISOTOPES
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