Postoperative irradiation for squamous cell carcinomas of the head and neck: analysis of time-dose factors related to control above the clavicles
The combination of radical surgery followed by postoperative irradiation is commonly employed in the treatment of advanced heat and neck cancers. However, there has been little in the literature concerning the dose required to prevent recurrence after operation. A retrospective analysis of 71 patients with squamous cell carcinoma of the oral cavity, oropharynx, pyriform sinus, supraglottic larynx, and glottic larynx who were treated by surgery and postoperative irradiation attempted to define the time-dose relationship required to prevent recurrence. The failure rate above the clavicles decreased with increasing dose up to 7000 rad. The effect on control of positve surgical margins, bone and cartilage invasion, neck staging, perineural extension, perinodal extension, and split-course technique was reviewed; both positive surgical margins and split-course technique were found to be associated with a decrease in local control at every dose level below 6500 rad. The complications of combined therapy were foound to be independent of dose. From these analyses, dose recommendations for various clinical situations are made, as well as recommendations for adjustments in radiation techniques to take advantage of the predictable sites of recurrence.
- Research Organization:
- Univ. of Florida, Gainesville
- OSTI ID:
- 5473777
- Journal Information:
- Int. J. Radiat. Oncol., Biol. Phys.; (United States), Vol. 5:11-12; Conference: 20. annual meeting of the American Society of Therapeutic Radiologists, Los Angeles, CA, USA, Nov 1978
- Country of Publication:
- United States
- Language:
- English
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62 RADIOLOGY AND NUCLEAR MEDICINE
CARCINOMAS
RADIOTHERAPY
HEAD
X RADIATION
NECK
DATA
DOSE-RESPONSE RELATIONSHIPS
PATIENTS
SIDE EFFECTS
SURGERY
TABLES
TIME DEPENDENCE
BODY
BODY AREAS
DATA FORMS
DISEASES
ELECTROMAGNETIC RADIATION
INFORMATION
IONIZING RADIATIONS
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
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RADIOLOGY
THERAPY
560151* - Radiation Effects on Animals- Man
550603 - Medicine- External Radiation in Therapy- (1980-)