Growth is compromised in rats fed ozone-treated casein
- Hokkaido Univ., Sapporo (Japan)
Modified casein containing few phenylalanine residues and no other aromatic amino acid residues was obtained by ozonolysis of casein. Although 68% of phenylalanine was decomposed by ozonolysis of casein, ozonolysis caused alterations beyond the destruction of aromatic amino acid residues. Nearly the same degree of decomposition of amino acid residues was observed in casein ozonated after predigestion by pepsin. Rats were fed diets containing 8% casein supplemented with methionine and aspartic acid (8C-AA), 8% ozonated casein supplemented with methionine and free amino acids lost by ozonolysis (8OC-AA), 8% casein ozonated after predigestion by pepsin supplemented with methionine and free amino acids lost during preparation (8POC-AA) or 7.6% amino acid mixture. The growth of rats fed the 8OC-AA diet was significantly lower than that of those fed 8C-AA or 7.6AA diets. The growth of rats fed the 8POC-AA diet was comparable to growth of those fed 8OC-AA. The biological values of the 8OC-AA and 8POC-AA were comparable to that of 8C-AA, but true digestibility of 8OC-AA was significantly lower than that of 8C-AA. True digestibility 8POC-AA was significantly improved relative to 8OC-AA, but the growth of rats fed 8POC-AA was not improved relative to that of those fed 8OC-AA. Kidney and cecum weights of rats fed 8OC-AA and 8POC-AA were significantly heavier than those of the 8C-AA-fed group, although histopathological examination of kidneys showed no deterioration compared to that of the 8C-AA-fed group.
- OSTI ID:
- 6523919
- Journal Information:
- Journal of Nutrition; (United States), Vol. 123:5; ISSN 0022-3166
- Country of Publication:
- United States
- Language:
- English
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59 BASIC BIOLOGICAL SCIENCES
CASEIN
OZONIZATION
OZONE
BIOLOGICAL EFFECTS
INGESTION
RATS
DIET
GROWTH
AMINO ACIDS
ASPARTIC ACID
KIDNEYS
METHIONINE
PEPSIN
PHENYLALANINE
ACID PROTEINASES
ANIMALS
BODY
CARBOXYLIC ACIDS
CHEMICAL REACTIONS
DRUGS
ENZYMES
HYDROLASES
INTAKE
LIPOTROPIC FACTORS
MAMMALS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC PHOSPHORUS COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANS
PEPTIDE HYDROLASES
PROTEINS
RODENTS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology
550200 - Biochemistry