Further studies on the interactions among dietary aluminum, boron, magnesium, and methionine in the rat

Conference · Fri Feb 28 23:00:00 EST 1986 · Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States)

OSTI ID:5316154

Nielsen, F H

An experiment was done to confirm findings that dietary B affects the response of rats to Mg deprivation and/or high dietary Al and that the response is influenced by methionine status. Weanling Sprague-Dawley rats were fed for 49 days a diet based on 70% acid-washed ground corn - 16% casein with the following supplements factorially arranged as variables: B, 0 and 3 ..mu..g/g; Al, 0 and 1000 ..mu..g/g; Mg, 100 and 400 ..mu..g/g; and amino acids, none, 2.5 methionine (Met)/g and 5 mg arginine (Arg)/g. When compared to an earlier experiment, the low Mg was lower, the high Al was higher, and Arg was an addition to exacerbate low Met status. Mg deficiency depressed growth and elevated the spleen wt/body wt, liver wt/body wt, and kidney wt/body wt ratios. The changes were more marked in B-deprived than B-supplemented rats. Also, the differences due to dietary B were most marked when Met was marginal or possibly deficient. High dietary Al depressed growth. The depression was most marked when the diet was Mg-deficient for B-supplemented rats, but was most marked when the diet was Mg-adequate for B-deprived rats. Apparently, the growth depression caused by Mg deficiency in the B-deprived rats prevented any further significant growth depression by high dietary Al. The findings indicate that B might be beneficial in conditions that can cause a hyperparathyroid state in the rat.

• Research Organization: Dept. of Agriculture, Grand Forks, ND
• OSTI ID: 5316154
• Report Number(s): CONF-8604222-
• Journal Information: Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States), Journal Name: Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States) Vol. 45:3; ISSN FEPRA
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKALINE EARTH METALS
ALUMINIUM
AMINO ACIDS
ANIMAL GROWTH
ANIMALS
ARGININE
BIOLOGICAL EFFECTS
BODY
BORON
CARBOXYLIC ACIDS
DIET
DIGESTIVE SYSTEM
DRUGS
ELEMENTS
GLANDS
GROWTH
KIDNEYS
LIPOTROPIC FACTORS
LIVER
MAGNESIUM
MAMMALS
METALS
METHIONINE
NUTRITIONAL DEFICIENCY
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANS
RATS
RODENTS
SEMIMETALS
SPLEEN
TOXICITY
VERTEBRATES
WEIGHT