Utilization of /sup 14/C-tyrosine in brain and peripheral tissues of developmentally protein malnourished rats

Journal Article · Wed Nov 01 04:00:00 EST 1978 · Brain Res. Bull.; (United States)

DOI:https://doi.org/10.1016/0361-9230(78)90017-5· OSTI ID:6463750

Miller, M; Leahy, J P; McConville, F; Morgane, P J; Resnick, O

Prior studies of developmentally protein malnourished rats have reported substantial changes in brain and peripheral utilization of /sup 14/C-leucine, /sup 14/C-phenylalanine, and /sup 14/C-tryptophan. In the present study rats born to dams fed a low protein diet (8% casein) compared to the offspring of control rats fed a normal diet (25% casein) showed few significant differences in the uptake and incorporation of /sup 14/C-tyrosine into brain and peripheral tissues from birth to age 21 days. At birth, the 8% casein pups exhibited significant decreases in brain and peripheral tissue incorporation of tracer only at short post-injection times (10 and 20 min), but not at longer intervals (90 and 180 min). During ontogenetic development (Days 5-21), the 8% casein rats showed significant increases in uptake of /sup 14/C-tyrosine into the brain and peripheral tissues on Day 11 and a significantly higher percent incorporation of tracer into brain protein on Day 21 as compared to the 25% casein rats. For the most part, there were no significant changes in incorporation of radioactivity in peripheral tissues for the 2 diet groups on these post-birth days. Overall, the data indicates that developmental protein malnutrition causes relatively fewer changes in brain and peripheral utilization of the semi-essential amino acid tyrosine than those observed in previous studies with essential amino acids.

• Research Organization: Worcester Foundation for Experimental Biology, Shrewsbury, MA (USA)
• OSTI ID: 6463750
• Journal Information: Brain Res. Bull.; (United States), Journal Name: Brain Res. Bull.; (United States) Vol. 3:6; ISSN BRBUD
• Country of Publication: United States
• Language: English

Related Subjects

550501* -- Metabolism-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
AMINO ACIDS
ANIMALS
BODY
BRAIN
CARBON 14 COMPOUNDS
CARBOXYLIC ACIDS
CENTRAL NERVOUS SYSTEM
HYDROXY ACIDS
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
MAMMALS
METABOLISM
NERVOUS SYSTEM
NUTRITION
NUTRITIONAL DEFICIENCY
ONTOGENESIS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PROTEINS
RATS
RODENTS
TRACER TECHNIQUES
TYROSINE
VERTEBRATES