Immunoreactive somatostatin and. beta. -endorphin content in the brain of mature rats after neonatal exposure to propylthiouacil. [Propylthiouracil]
The contents of immunoreactive somatostatin (IR-SRIF) and ..beta..-endorphin (IR-..beta..-EP) in 12 brain regions were examined in rats exposed neonatally to propylthiouracil (PTU) through the mother's milk. Since the dose of PTU used in this study is lower than the usual dose employed to induce hypothyroidism, a milder form of neonatal hypothyroidism resulted. This conclusion is supported by the only mild subnormal growth of rats to adulthood and serum T/sub 4/ and T/sub 3/ concentrations in the normal range. Adult rats treated with PTU neonatally had significantly higher IR-SRIF contents in several brain regions compared to controls, whereas IR-..beta..-EP levels were not significantly different in most regions. The results indicate that even mild hypothyroidism during early postnatal development causes permanent impairment of brain function, which manifests itself in part by an altered brain content of IR-SRIF.
- Research Organization:
- Univ. of Manitoba, Winnipeg
- DOE Contract Number:
- AS05-76EV01643
- OSTI ID:
- 6477937
- Journal Information:
- Endocrinology; (United States), Vol. 110:6
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
ENDORPHINS
BIOCHEMISTRY
SOMATOSTATIN
URACILS
BIOLOGICAL EFFECTS
BRAIN
HYPOTHYROIDISM
MILK
NEONATES
RATS
THYROXINE
TRIIODOTHYRONINE
AMINO ACIDS
ANIMALS
AUTONOMIC NERVOUS SYSTEM AGENTS
AZINES
BIOLOGICAL MATERIALS
BODY
BODY FLUIDS
CARBOXYLIC ACIDS
CENTRAL NERVOUS SYSTEM
CHEMISTRY
DISEASES
DRUGS
ENDOCRINE DISEASES
FOOD
HETEROCYCLIC COMPOUNDS
HORMONES
HYDROXY COMPOUNDS
MAMMALS
MATERIALS
NERVOUS SYSTEM
NEUROREGULATORS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC IODINE COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PEPTIDE HORMONES
PYRIMIDINES
RODENTS
THYROID HORMONES
VERTEBRATES
551000* - Physiological Systems