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The effects of cysteamine on thyrotropin and immunoreactive beta-endorphin secretion in the rat

Journal Article · · Endocrinology; (United States)
OSTI ID:6250263
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We examined the effects of the thiol agent cysteamine (CSH), which is known to deplete the hypothalamus of immunoreactive somatostatin, on physiological TSH and beta- endorphin secretion in the adult male rat. CSH at doses of 90 and 300 mg/kg CSH produced a rapid decline in plasma TSH, whereas a dose of 30 mg/kg did not alter plasma TSH levels. After the higher doses of CSH, TSH levels in the blood remained lower than control values on day 2, but returned to normal by 1 week. This decrease in TSH within the plasma was not associated with a reduction in hypothalamic TRH concentrations. The TSH response to 500 ng/kg TRH was normal in CSH-treated animals. Blockade of norepinephrine synthesis with diethyldithiocarbamate (500 mg/kg) or fusaric acid (100 mg/kg) inhibited TSH secretion in a manner similar to that of CSH. beta-Endorphin-like immunoreactivity (bet-End-LI) was elevated in the plasma immediately after CSH (300 mg/kg) administration. This was associated with a 58% reduction in anterior pituitary beta-End-LI and no change in hypothalmic beta-End-LI. Plasma beta-End-LI returned to normal on day 2. The increase in plasma beta-End-LI induced by immobilization stress was not compromised by CSH treatment. The observed effects of CSH on both TSH and beta-End-LI are consistent with a reduction in central norepinephrine neurotransmission through the known actin of CSH to inhibit dopamine-beta-hydroxylase. Acute stress may play a role as well in the observed changes in TSH and beta-End-LI secretion.

Research Organization:
Department of Neurology, Massachusetts General Hospital, Boston
OSTI ID:
6250263
Journal Information:
Endocrinology; (United States), Journal Name: Endocrinology; (United States) Vol. 112:2; ISSN ENDOA
Country of Publication:
United States
Language:
English

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Related Subjects

560306* -- Chemicals Metabolism & Toxicology-- Man-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINES
AUTONOMIC NERVOUS SYSTEM AGENTS
BIOCHEMISTRY
BIOELECTRICITY
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL PATHWAYS
BLOOD
BLOOD PLASMA
BODY
BODY FLUIDS
BRAIN
CENTRAL NERVOUS SYSTEM
CHEMISTRY
DOSE-RESPONSE RELATIONSHIPS
DRUGS
ELECTRICITY
ENDORPHINS
ENZYME ACTIVITY
HORMONES
HYPOTHALAMUS
INHIBITION
MATERIALS
MEA
NERVOUS SYSTEM
NEUROREGULATORS
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANS
PEPTIDE HORMONES
PITUITARY HORMONES
RADIOPROTECTIVE SUBSTANCES
SECRETION
SOMATOSTATIN
THIOLS
TOXICITY
TRH
TSH