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Ionizing radiation alters beta-endorphin-like immunoreactivity in brain but not blood

Journal Article · · Pharmacol., Biochem. Behav.; (United States)
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Previous behavioral and pharmacological studies have implicated endorphins in radiation-induced locomotor hyperactivity of the C57BL/6J mouse. However, the endogenous opiate(s) responsible for this behavioral change have not been identified. The present study measured beta-endorphin-like immunoreactivity (beta-END-LI) in brain, blood, and combined brain and pituitary samples from irradiated and sham-irradiated C57BL/6J mice. After radiation exposure, levels of beta-END-LI decreased significantly in the brain. A similar, but not statistically significant, decline was measured in combined brain and pituitary samples. Concentrations of blood beta-END-LI were not changed by irradiation. These radiogenic changes in beta-END-LI are in some ways similar to those observed after other stresses. However, radiation-induced locomotor hyperactivity may be mediated more by alterations of beta-END-LI in the brain than in the periphery. Other endogenous opiate systems may also contribute to this behavioral change in the C57BL/6J mouse.

Research Organization:
US Air Force Academy, Colorado Springs, CO
OSTI ID:
6470445
Journal Information:
Pharmacol., Biochem. Behav.; (United States), Journal Name: Pharmacol., Biochem. Behav.; (United States) Vol. 19:6; ISSN PBBHA
Country of Publication:
United States
Language:
English

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Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
AUTONOMIC NERVOUS SYSTEM AGENTS
BEHAVIOR
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BLOOD
BODY
BODY FLUIDS
BRAIN
CENTRAL NERVOUS SYSTEM
DRUGS
ENDOCRINE GLANDS
GLANDS
IMMUNE REACTIONS
IONIZING RADIATIONS
KINETICS
MAMMALS
MATERIALS
MICE
NERVOUS SYSTEM
ORGANS
PITUITARY GLAND
RADIATION EFFECTS
RADIATIONS
REACTION KINETICS
RODENTS
SYMPATHOMIMETICS
VERTEBRATES