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Endogenous opiates mediate radiogenic behavioral change

Journal Article · · Science (Washington, D.C.); (United States)
; ; ;

Exposure of C57BL/6J mice to ionizing radiation caused stereotypical locomotor hyperactivity similar to that produced by morphine. Naloxone administration prevented this radiation-induced behavioral activation. These results support the hypothesis that endorphins are involved in some aspects of radiogenic behavioral change.

Research Organization:
Air Force Academy, Colorado Springs, CO
OSTI ID:
6201139
Journal Information:
Science (Washington, D.C.); (United States), Journal Name: Science (Washington, D.C.); (United States) Vol. 220; ISSN SCIEA
Country of Publication:
United States
Language:
English

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Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKALOIDS
ANALGESICS
ANIMALS
AUTONOMIC NERVOUS SYSTEM AGENTS
BEHAVIOR
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CENTRAL NERVOUS SYSTEM DEPRESSANTS
DRUGS
ENDORPHINS
IONIZING RADIATIONS
MAMMALS
MICE
MORPHINE
NARCOTICS
NEUROREGULATORS
OPIUM
ORGANIC COMPOUNDS
RADIATION EFFECTS
RADIATIONS
RADIOSENSITIVITY EFFECTS
RODENTS
VERTEBRATES