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Endogenous opiates mediate radiogenic behavioral change. [Mice]

Journal Article · · Science (Washington, D.C.); (United States)
; ; ;

Exposure of C57BL/6J mice to ionizing radiation caused stereotypical locomotor hyperactivity similar to that produced by morphine. Naloxone administration prevented this radiation-induced behavioral activation. These results support the hypothesis that endorphins are involved in some aspects of radiogenic behavioral change.

Research Organization:
US Air Force Academy, Colorado Springs
OSTI ID:
5096258
Journal Information:
Science (Washington, D.C.); (United States), Journal Name: Science (Washington, D.C.); (United States) Vol. 220:4602; ISSN SCIEA
Country of Publication:
United States
Language:
English

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Related Subjects

550200 -- Biochemistry
560152* -- Radiation Effects on Animals-- Animals
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
AUTONOMIC NERVOUS SYSTEM AGENTS
BEHAVIOR
BIOCHEMISTRY
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CHEMISTRY
DRUGS
ENDORPHINS
IONIZING RADIATIONS
MAMMALS
MICE
NEUROREGULATORS
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RODENTS
VERTEBRATES