Immunoreactive somatostatin and. beta. -endorphin content in the brain of mature rats after neonatal exposure to propylthiouracil

Journal Article · Tue Jun 01 04:00:00 EDT 1982 · Endocrinology; (United States)

OSTI ID:6776645

Kato, N ^[1]; Sundmark, V C; Van Middlesworth, L; Havlicek, V; Friesen, H G

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1. Univ. of Manitoba, Winnipeg, Canada

The contents of immunoreactive somatostatin (IR-SRIF) and ..beta..-endorphin (IR-..beta..-EP) in 12 brain regions were examined in rats exposed neonatally to propylthiouracil (PTU) through the mother's milk. Since the dose of PTU used in the study is lower than the usual dose employed to induce hypothyroidism, a milder form of neonatal hypothyroidism resulted. This conclusion is supported by the only mild subnormal growth of rats to adulthood and serum T/sub 4/ and T/sub 3/ concentrations in the normal range. Adult rats treated with PTU neonatally had significantly higher IR-SRIF contents in several brain regions compared to controls, whereas IR-..beta..-EP levels were not significantly different (significant increase only in the thalamus) in most regions. The results indicate that even mild hypothyroidism during early postnatal development causes permanent impairment of brain function, which manifests itself in part by an altered brain content of IR-SRIF.

• OSTI ID: 6776645
• Journal Information: Endocrinology; (United States), Journal Name: Endocrinology; (United States) Vol. 110:6; ISSN ENDOA
• Country of Publication: United States
• Language: English

Related Subjects

551000 -- Physiological Systems
560306* -- Chemicals Metabolism & Toxicology-- Man-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADULTS
AGE GROUPS
ALKYL RADICALS
ANIMALS
ANTIMETABOLITES
ANTITHYROID DRUGS
AUTONOMIC NERVOUS SYSTEM AGENTS
AZINES
BIOLOGICAL EFFECTS
BIOLOGICAL LOCALIZATION
BIOLOGICAL MATERIALS
BODY
BODY FLUIDS
BRAIN
CENTRAL NERVOUS SYSTEM
CONCENTRATION RATIO
DISEASES
DRUGS
ENDOCRINE DISEASES
ENDORPHINS
FOOD
HETEROCYCLIC COMPOUNDS
HORMONE ANTAGONISTS
HYDROXY COMPOUNDS
HYPOTHYROIDISM
IMMUNE REACTIONS
MAMMALS
MATERIALS
MILK
NEONATES
NERVOUS SYSTEM
NEUROREGULATORS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANS
PATHOLOGICAL CHANGES
PROPYL RADICALS
PYRIMIDINES
RADICALS
RATS
RODENTS
SOMATOSTATIN
THIOLS
THIOURACIL
URACILS
VERTEBRATES