Immunoreactive somatostatin and. beta. -endorphin content in the brain of mature rats after neonatal exposure to propylthiouacil. [Propylthiouracil]
Journal Article
·
· Endocrinology; (United States)
OSTI ID:6477937
The contents of immunoreactive somatostatin (IR-SRIF) and ..beta..-endorphin (IR-..beta..-EP) in 12 brain regions were examined in rats exposed neonatally to propylthiouracil (PTU) through the mother's milk. Since the dose of PTU used in this study is lower than the usual dose employed to induce hypothyroidism, a milder form of neonatal hypothyroidism resulted. This conclusion is supported by the only mild subnormal growth of rats to adulthood and serum T/sub 4/ and T/sub 3/ concentrations in the normal range. Adult rats treated with PTU neonatally had significantly higher IR-SRIF contents in several brain regions compared to controls, whereas IR-..beta..-EP levels were not significantly different in most regions. The results indicate that even mild hypothyroidism during early postnatal development causes permanent impairment of brain function, which manifests itself in part by an altered brain content of IR-SRIF.
- Research Organization:
- Univ. of Manitoba, Winnipeg
- DOE Contract Number:
- AS05-76EV01643
- OSTI ID:
- 6477937
- Journal Information:
- Endocrinology; (United States), Journal Name: Endocrinology; (United States) Vol. 110:6; ISSN ENDOA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
551000* -- Physiological Systems
59 BASIC BIOLOGICAL SCIENCES
AMINO ACIDS
ANIMALS
AUTONOMIC NERVOUS SYSTEM AGENTS
AZINES
BIOCHEMISTRY
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BODY
BODY FLUIDS
BRAIN
CARBOXYLIC ACIDS
CENTRAL NERVOUS SYSTEM
CHEMISTRY
DISEASES
DRUGS
ENDOCRINE DISEASES
ENDORPHINS
FOOD
HETEROCYCLIC COMPOUNDS
HORMONES
HYDROXY COMPOUNDS
HYPOTHYROIDISM
MAMMALS
MATERIALS
MILK
NEONATES
NERVOUS SYSTEM
NEUROREGULATORS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC IODINE COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PEPTIDE HORMONES
PYRIMIDINES
RATS
RODENTS
SOMATOSTATIN
THYROID HORMONES
THYROXINE
TRIIODOTHYRONINE
URACILS
VERTEBRATES
59 BASIC BIOLOGICAL SCIENCES
AMINO ACIDS
ANIMALS
AUTONOMIC NERVOUS SYSTEM AGENTS
AZINES
BIOCHEMISTRY
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BODY
BODY FLUIDS
BRAIN
CARBOXYLIC ACIDS
CENTRAL NERVOUS SYSTEM
CHEMISTRY
DISEASES
DRUGS
ENDOCRINE DISEASES
ENDORPHINS
FOOD
HETEROCYCLIC COMPOUNDS
HORMONES
HYDROXY COMPOUNDS
HYPOTHYROIDISM
MAMMALS
MATERIALS
MILK
NEONATES
NERVOUS SYSTEM
NEUROREGULATORS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC IODINE COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PEPTIDE HORMONES
PYRIMIDINES
RATS
RODENTS
SOMATOSTATIN
THYROID HORMONES
THYROXINE
TRIIODOTHYRONINE
URACILS
VERTEBRATES