Endogenous opiates mediate radiogenic behavioral change

Journal Article · Sun Jul 10 00:00:00 EDT 1983 · Science (Washington, D.C.); (United States)

DOI:https://doi.org/10.1126/science.6857244· OSTI ID:6201139

Mickley, G A; Stevens, K E; White, G A; Gibbs, G L

Exposure of C57BL/6J mice to ionizing radiation caused stereotypical locomotor hyperactivity similar to that produced by morphine. Naloxone administration prevented this radiation-induced behavioral activation. These results support the hypothesis that endorphins are involved in some aspects of radiogenic behavioral change.

• Research Organization: Air Force Academy, Colorado Springs, CO
• OSTI ID: 6201139
• Journal Information: Science (Washington, D.C.); (United States), Vol. 220
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ENDORPHINS
RADIOSENSITIVITY EFFECTS
MICE
BEHAVIOR
BIOLOGICAL RADIATION EFFECTS
IONIZING RADIATIONS
MORPHINE
ALKALOIDS
ANALGESICS
ANIMALS
AUTONOMIC NERVOUS SYSTEM AGENTS
BIOLOGICAL EFFECTS
CENTRAL NERVOUS SYSTEM DEPRESSANTS
DRUGS
MAMMALS
NARCOTICS
NEUROREGULATORS
OPIUM
ORGANIC COMPOUNDS
RADIATION EFFECTS
RADIATIONS
RODENTS
VERTEBRATES
560152* - Radiation Effects on Animals- Animals