Response of human fibroblasts to low dose rate gamma irradiation
Cells from 11 human strains, including fibroblasts from patients with the genetic diseases of ataxia telangiectasia (AT), xeroderma pigmentosum (XP), and Fanconi's anemia (FA), were exposed to ..gamma.. radiation at high (1.6-2.2 Gy/min) and at low (0.03-0.07 Gy/min) dose rates. Survival curves reveal an increase inthe terminal slope (D/sub 0/) when cells are irradiated at low dose rates compared to high dose rates. This was true for all cell lines tested, although the AT, FA, and XP cells are reported or postulated to have radiation repair deficiencies. From the response of these cells, it is apparent that radiation sensitivities differ; however, at low dose rate, all tested human cells are able to repair injury.
- Research Organization:
- Georgetown Univ. Medical Center, Washington, DC
- OSTI ID:
- 6054894
- Journal Information:
- Radiat. Res.; (United States), Vol. 100:2
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
CELL KILLING
RADIOINDUCTION
FIBROBLASTS
RADIOSENSITIVITY
ANEMIAS
BIOLOGICAL REPAIR
COBALT 60
DOSE RATES
EXPERIMENTAL DATA
GAMMA RADIATION
LOW DOSE IRRADIATION
MAN
SURVIVAL CURVES
TELANGIECTASIS
XP CELLS
ANIMAL CELLS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL RECOVERY
COBALT ISOTOPES
CONNECTIVE TISSUE CELLS
DATA
DISEASES
ELECTROMAGNETIC RADIATION
HEMIC DISEASES
INFORMATION
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IONIZING RADIATIONS
IRRADIATION
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
MINUTES LIVING RADIOISOTOPES
NUCLEI
NUMERICAL DATA
ODD-ODD NUCLEI
PRIMATES
RADIATIONS
RADIOISOTOPES
RECOVERY
REPAIR
SKIN DISEASES
SOMATIC CELLS
SYMPTOMS
VASCULAR DISEASES
VERTEBRATES
YEARS LIVING RADIOISOTOPES
560121* - Radiation Effects on Cells- External Source- (-1987)