Chromosomal radiosensitivity during the G2 cell-cycle period of skin fibroblasts from individuals with familial cancer
The authors reported previously that human cells after neoplastic transformation in culture had acquired an increased susceptibility to chromatid damage induced by x-irradiation during the G2 phase of the cell cycle. Evidence suggested that this results from deficient DNA repair during G2 phase. Cells derived from human tumors also showed enhanced G2-phase chromosomal radiosensitivity. Furthermore, skin fibroblasts from individuals with genetic diseases predisposing to a high risk of cancer, including ataxia-telangiectasia, Bloom syndrome, Fanconi anemia, and xeroderma pigmentosum exhibited enhanced G2-phase chromosomal radiosensitivity. The present study shows that apparently normal skin fibroblasts from individuals with familial cancer--i.e., from families with a history of neoplastic disease--also exhibit enhanced G2-phase chromosomal radiosensitivity. This radiosensitivity appears, therefore, to be associated with both a genetic predisposition to cancer and a malignant neoplastic state. Furthermore, enhanced G2-phase chromosomal radiosensitivity may provide the basis for an assay to detect genetic susceptibility to cancer.
- Research Organization:
- Howard Univ. College of Medicine, Washington, DC
- OSTI ID:
- 5017305
- Journal Information:
- Proc. Natl. Acad. Sci. U.S.A.; (United States), Vol. 16
- Country of Publication:
- United States
- Language:
- English
Similar Records
A deficiency in chromatin repair, genetic instability, and predisposition to cancer
Repair of damaged DNA in vivo: Final technical report
Related Subjects
CHROMOSOMES
RADIOSENSITIVITY
CELL CYCLE
CHROMATIDS
DNA REPAIR
FIBROBLASTS
NEOPLASMS
RISK ASSESSMENT
SKIN
X RADIATION
ANIMAL CELLS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
BODY
CONNECTIVE TISSUE CELLS
DISEASES
ELECTROMAGNETIC RADIATION
IONIZING RADIATIONS
ORGANS
RADIATIONS
RECOVERY
REPAIR
SOMATIC CELLS
560121* - Radiation Effects on Cells- External Source- (-1987)