Increased production of plasminogen activator inhibitor in vitro by pleural leukocytes from rats intratracheally instilled with crocidolite asbestos
- Inst. of Occupational Medicine, Edinburgh (Scotland)
- Univ. of Edinburgh (Scotland)
The authors have previously reported that normal pleural leukocytes secrete a urokinase-type plasminogen activator inhibitor (PAI) in culture. In view of the pathogenic effects of asbestos on the pleura, in particular pleural fibrosis, they have extended these observation to crocidolite asbestos-exposed rats. Pleural leukocytes from rats exposed to crocidolite asbestos were found to secrete more PAI in culture than controls. The activity of PAI in pleural leukocyte-conditioned medium increased in a dose-dependent manner in relation to the quantity of asbestos injected into the lung. However, with increasing time post asbestos instillation, there was no significant change in the secretion of PAI by pleural leukocytes in culture compared with earlier time points of crocidolite-exposed rats. Plasminogen activator was not detectable in the conditioned medium at any time point. The data derived from this study may help to elucidate the pathogenesis of some pleural disorders caused by exposure to fibrous dusts in the lungs.
- OSTI ID:
- 6024398
- Journal Information:
- Environmental Research; (United States), Vol. 55:2; ISSN 0013-9351
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
ASBESTOS
TOXICITY
DOSE-RESPONSE RELATIONSHIPS
ENZYME INHIBITORS
FIBERS
IN VITRO
INTRATRACHEAL ADMINISTRATION
LEUKOCYTES
PATHOGENESIS
PLASMINOGEN
PLEURA
RATS
RESPIRATORY SYSTEM DISEASES
ANIMALS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BLOOD COAGULATION FACTORS
BODY FLUIDS
COAGULANTS
DISEASES
DRUGS
FIBRINOLYTIC AGENTS
HEMATOLOGIC AGENTS
MAMMALS
MATERIALS
MEMBRANES
ORGANIC COMPOUNDS
PROTEINS
RODENTS
SEROUS MEMBRANES
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology