Tumor incidence was not related to the thickness of visceral pleural in female Syrian hamsters intratracheally administered amphibole asbestos or manmade fibers

Journal Article · Mon Jun 01 04:00:00 EDT 1992 · Environmental Research; (United States)

DOI:https://doi.org/10.1016/S0013-9351(05)80204-X· OSTI ID:7159290

Adachi, Shuichi; Kawamura, K; Takemoto, Kazuo ^[1]; Kimura, Kikuzi ^[2]

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1. Saitama Medical School, Morohongo (Japan)
2. Inst. of Science for Labor, Kawasaki (Japan)

Histological observations were performed on female Syrian hamsters 2 years after the intratracheal administration of amphibole asbestos, amosite, and crocidolite to evaluate the tumorigenicity of six types of fine manmade fibers (reported previously). A mesothelioma and a lung tumor were induced in 20 animals administered amosite, but no tumors were found in the crocidolite group. Because this incidence is not higher than that of manmade fibers, such as basic magnesium sulfate fiber (9 tumor-bearing hamsters in 20 hamsters (9/20)), metaphosphate fiber (5/20), calcium sulfate fiber (3.20), and fiberglass (2/20), it is suggested that some types of manmade fibers have a greater ability than asbestos to induce tumors. Moreover, as a specific observation in manmade fiber groups, tumors were induced at intracelial organs rather than at the pleural cavity. On the other hand, the average thickness of visceral pleura was higher in all asbestos and manmade fiber groups than in the control (2.9 {mu}m), for instance, 36.95 {mu}m in potassium titanate fiber group, 15.90 {mu}m crocidolite group, 13.00 {mu}m basic magnesium sulfate fiber group, and 10.45 {mu} in the rockwool group. Although both pleural thickening and mesotherlioma were known as peculiar lesions in asbestos-exposed people, it might also be suggested that these lesions could be induced by different mechanisms from the result that there was no relation between the pleural thickening and mesothelioma incidence in hamsters.

• OSTI ID: 7159290
• Journal Information: Environmental Research; (United States), Journal Name: Environmental Research; (United States) Vol. 58:1; ISSN ENVRA; ISSN 0013-9351
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
ASBESTOS
BODY
CARCINOGENESIS
COMPARATIVE EVALUATIONS
DISEASE INCIDENCE
DISEASES
EVALUATION
FIBERS
HAMSTERS
INTRATRACHEAL ADMINISTRATION
LUNGS
MAMMALS
NEOPLASMS
ORGANS
PATHOGENESIS
PATHOLOGICAL CHANGES
RESPIRATORY SYSTEM
RODENTS
VERTEBRATES