Tumorigenicity of fine man-made fibers after intratracheal administrations to hamsters

Journal Article · Fri Feb 01 04:00:00 EST 1991 · Environmental Research; (United States)

DOI:https://doi.org/10.1016/S0013-9351(05)80194-X· OSTI ID:5740685

Adachi, Shuichi; Takemoto, Kazuo ^[1]; Kimura, Kikuzi ^[2]

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1. Saitama Medical School, Iruma (Japan)
2. Inst. of Science for Labor, Kawasaki (Japan)

Six types of man-made fibers were administered intratracheally (2.0 mg/animal each a week, for 5 weeks; total 10 mg/animal) to female Syrian hamsters that were observed histologically for 2 years after administration. The fibers were rock wool, fiberglass, potassium titanate fiber, calcium sulfate fiber, basic magnesium sulfate fiber, and metaphosphate fiber. Tumors were observed in hamsters that had received basic magnesium sulfate fiber (9/20), metaphosphate fiber (6/20), calcium sulfate fiber (3/20), and fiberglass (2/20) but not in the control, rock wool, or potassium titanate fiber groups. The primary sites of the tumors were not only in the pleural cavity but also in the intracelial organs, kidney, adrenal gland, bladder, and uterus. Only a few of the tumors were identified as mesotheliomas, by histological examination. In addition to neoplastic lesions, fibrosis, pleural thickening, and chronic inflammatory changes in the lungs were observed in the hamsters, but these changes appeared too mild to foster a pneumoconiosis such as asbestosis.

• OSTI ID: 5740685
• Journal Information: Environmental Research; (United States), Journal Name: Environmental Research; (United States) Vol. 54:1; ISSN ENVRA; ISSN 0013-9351
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADRENAL GLANDS
ANIMALS
BLADDER
BODY
CARCINOGENESIS
ENDOCRINE GLANDS
FEMALE GENITALS
FIBERS
GLANDS
HAMSTERS
INTRATRACHEAL ADMINISTRATION
KIDNEYS
LUNGS
MAMMALS
MATERIALS
ORGANS
PATHOGENESIS
RESPIRATORY SYSTEM
RODENTS
SIZE
SYNTHETIC MATERIALS
URINARY TRACT
UTERUS
VERTEBRATES