Induction of angiogenesis by intraperitoneal injection of asbestos fibers

Journal Article · Sat Apr 01 04:00:00 EST 1989 · FASEB Journal (Federation of American Societies for Experimental Biology); (USA)

OSTI ID:7005443

Branchaud, R M; Macdonald, J L; Kane, A B ^[1]

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1. Brown Univ., Providence, Rhode Island (USA)

Tumors and activated macrophages release angiogenic factors that stimulate migration and proliferation of capillaries. We studied the development of angiogenesis before the appearance of mesotheliomas in C57B1/6 mice. Weekly i.p. injections of crocidolite asbestos fibers produced mesotheliomas after 30-50 wk. The initial histologic response to asbestos fibers was a nodular lesion on the peritoneal lining composed of clusters of fibers, activated macrophages, and proliferating mesenchymal cells. The earliest visible evidence of angiogenesis was seen surrounding 7% of these lesions 14 days after a single injection of 200 {mu}g of crocidolite asbestos fibers. After six weekly injections, 30% of the lesions containing asbestos fibers were surrounded by a capillary network radiating toward the center of the lesion. Other mineral fibers, including chrysotile asbestos and fiberglass, also induced angiogensis after six weekly injections. In contrast, only 8% of the lesions containing short asbestos fibers (90.6% {le} 2.0 {mu}m) and 9% of the lesions containing silica particles showed evidence of angiogenesis. We conclude that tumorigenic mineral fibers induce angiogenesis in the peritoneal lining, where nontumorigenic mineral particles or short asbestos fibers are less effective. Ingrowth of new blood vessels around clusters of asbestos fibers may facilitate the later emergence of mesotheliomas at these sites.

• OSTI ID: 7005443
• Journal Information: FASEB Journal (Federation of American Societies for Experimental Biology); (USA), Journal Name: FASEB Journal (Federation of American Societies for Experimental Biology); (USA) Vol. 3:6; ISSN FAJOE; ISSN 0892-6638
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
ASBESTOS
BLOOD VESSELS
BODY
CARCINOGENESIS
CARDIOVASCULAR SYSTEM
CELL PROLIFERATION
CONNECTIVE TISSUE CELLS
DISEASES
ETIOLOGY
FIBERS
INJECTION
INTAKE
INTRAPERITONEAL INJECTION
MACROPHAGES
MAMMALS
MICE
NEOPLASMS
ORGANS
PATHOGENESIS
PATHOLOGICAL CHANGES
PHAGOCYTES
RODENTS
SOMATIC CELLS
TOXICITY
VERTEBRATES