Influence of retinol on carcinogen-induced sister chromatid exchangers and chromosome aberrations in V79 cells
The influence of retinol (Rol) on sister chromatid exchangers (SCE) in V79 cells induced by six indirect and two direct carcinogens, and on chromosome aberration (CA) in V79 cells induced by four indirect carcinogens were studied. The indirect carcinogens used were aflatoxin B/sub 1/ (AFB), cyclophosphamide (CPP), benzo(a)anthracene (BA), benzo(a)pyrene (BP), 9,10-dimethyl-1,2-benz(a)anthracene (DMBA), and 3-methylcholanthrene (MCA). The two direct carcinogens were ethyl methane sulfonate (EMS) and N-methyl-N'-nitro-N-nitrosoguanidine (MNNG). Rol effectively inhibited SCE and CA induced by AFB and CPP in a dose-dependent manner, but it had no effect on SCE induced by BA, BP, DMBA, MCA, EMS, and MNNG. To the contrary, Rol had an enhancing effect on CA induced by BP and DMBA. The possibility that Rol exerts its anticarcinogenic effects by inhibiting certain forms of the cytochrome P-450 isoenzymes required for activation of precarcinogens, such as AFB and CPP but not those enzymes required by BA, BP, DMBA, and MCA, is discussed.
- Research Organization:
- Roswell Park Memorial Institute, Buffalo, NY
- OSTI ID:
- 5748609
- Journal Information:
- Environ. Mutagen.; (United States), Vol. 7:2
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
3-METHYLCHOLANTHRENE
BIOLOGICAL EFFECTS
AFLATOXIN
BENZANTHRACENE
BENZOPYRENE
DIMETHYLBENZANTHRACENE
ENDOXAN
NITROSO COMPOUNDS
VITAMIN A
CHROMOSOMAL ABERRATIONS
DOSE-RESPONSE RELATIONSHIPS
FIBROBLASTS
SISTER CHROMATID EXCHANGES
ALKYLATING AGENTS
ANIMAL CELLS
ANTIGENS
AROMATICS
CONDENSED AROMATICS
CONNECTIVE TISSUE CELLS
DRUGS
HYDROCARBONS
IMMUNOSUPPRESSIVE DRUGS
MATERIALS
MUTATIONS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
POLYCYCLIC AROMATIC HYDROCARBONS
SOMATIC CELLS
TOXIC MATERIALS
TOXINS
VITAMINS
560301* - Chemicals Metabolism & Toxicology- Cells- (-1987)