AD6 (8-monochloro-3-beta-diethylamino-ethyl-4-methyl-7-ethoxycarbonyl-meth oxy coumarin) inhibits the release of arachidonic acid in human platelets stimulated by thrombin
The coumarin derivative AD6 is known to inhibit platelet aggregation and release and it possesses vasodilatory properties on coronary arteries of laboratory animals. Furthermore, the inhibition of the production of TxB2 from endogenous substrates after stimulation of human platelets with collagen has been demonstrated. The present report demonstrates that AD6 inhibits the production of labeled arachidonic acid and diglycerides from phospholipids of platelets stimulated with thrombin. This effect is dose-dependent and is already evident at a concentration of the drug (25 microM) which is unable to prevent the aggregation. Apparently, AD6 inhibits the release of arachidonic acid from phosphatidylinositol and choline phosphoglycerides which are the main sources of the substrate for the synthesis of prostaglandins and thromboxanes.
- Research Organization:
- Universita di Perugia, Italy
- OSTI ID:
- 5727530
- Journal Information:
- Thromb. Res.; (United States), Vol. 47:1
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
ARACHIDONIC ACID
SECRETION
BLOOD PLATELETS
BLOOD COAGULATION
COUMARINS
BIOLOGICAL FUNCTIONS
DOSE-RESPONSE RELATIONSHIPS
INHIBITION
PHOSPHOLIPIDS
RADIOISOTOPES
THROMBIN
TRACER TECHNIQUES
ANTICOAGULANTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CARBOXYLIC ACIDS
COAGULANTS
DRUGS
ENZYMES
ESTERS
FUNCTIONS
HEMATOLOGIC AGENTS
HEMOSTATICS
HYDROLASES
ISOTOPE APPLICATIONS
ISOTOPES
LIPIDS
MATERIALS
MONOCARBOXYLIC ACIDS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC PHOSPHORUS COMPOUNDS
PEPTIDE HYDROLASES
SERINE PROTEINASES
550201* - Biochemistry- Tracer Techniques