The effect of x rays, DTPA, and aspirin on the absorption of plutonium from the gastrointestinal tract of rats

Journal Article · Fri Apr 01 00:00:00 EST 1983 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3575866· OSTI ID:5504545

Sullivan, M F; Gorham, L S; Miller, B M

To measure the effect of radiation on plutonium transport, rats that were exposed to 250-kVp X rays were given /sup 238/Pu 3 days afterwards by either gavage or injection into a ligated segment of the duodenum. In a second group of experiments, rats were either injected intraduodenally with /sup 238/Pu-DTPA or administered the chelate intravenously and the /sup 238/Pu by gavage. In a third experiment, rats that had been gavaged with 200 or 400 mg/kg/day of aspirin for 2 days were injected intragastrically with /sup 238/Pu nitrate. Results of the first experiment showed a dose-dependent increase in /sup 238/Pu absorption between 800 and 1500 rad of lower-body X irradiation. Intravenous or intraduodenal injections of DTPA caused a marked increase in /sup 238/Pu absorption but resulted in decreased plutonium deposition in the skeleton and liver. Retention of /sup 238/Pu in the skeleton of rats given aspirin was double that of controls, but the effect on plutonium absorption was less marked than that of DTPA.

• Research Organization: Pacific Northwest Lab., Richland, WA
• DOE Contract Number: AC06-76RL01830
• OSTI ID: 5504545
• Journal Information: Radiat. Res.; (United States), Vol. 94:1
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACETYLSALICYLIC ACID
RADIOSENSITIVITY EFFECTS
DTPA
PLUTONIUM 238
INTESTINAL ABSORPTION
GASTROINTESTINAL TRACT
LIVER
PLUTONIUM NITRATES
RATS
SKELETON
X RADIATION
ABSORPTION
ACTINIDE COMPOUNDS
ACTINIDE ISOTOPES
ACTINIDE NUCLEI
ALPHA DECAY RADIOISOTOPES
AMINO ACIDS
ANALGESICS
ANIMALS
ANTIPYRETICS
BODY
CARBOXYLIC ACIDS
CENTRAL NERVOUS SYSTEM DEPRESSANTS
CHELATING AGENTS
DIGESTIVE SYSTEM
DRUGS
ELECTROMAGNETIC RADIATION
EVEN-EVEN NUCLEI
GLANDS
HEAVY NUCLEI
HYDROXY ACIDS
IONIZING RADIATIONS
ISOTOPES
MAMMALS
NITRATES
NITROGEN COMPOUNDS
NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
OXYGEN COMPOUNDS
PLUTONIUM COMPOUNDS
PLUTONIUM ISOTOPES
RADIATIONS
RADIOISOTOPES
RADIOPROTECTIVE SUBSTANCES
RODENTS
TRANSURANIUM COMPOUNDS
UPTAKE
VERTEBRATES
YEARS LIVING RADIOISOTOPES
560162* - Radionuclide Effects
Kinetics
& Toxicology- Animals
Plants
Microorganisms
& Cells