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Influence of oxidation state on the absorption of plutonium from the gastrointestinal tract. [/sup 238/Pu; /sup 239/Pu; rats; guinea pigs]

Journal Article · · Radiat. Res.; (United States)
DOI:https://doi.org/10.2307/3575120· OSTI ID:5673871
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A study was made of the effect of oxidation state on gastrointestinal absorption of plutonium using solutions that contained, or did not contain, a strong oxidant and animals that were or were not fasted. There was no appreciable difference in the absorption of intragastrically injected /sup 238/Pu(IV) and /sup 238/Pu(VI) by either rats or guinea pigs allowed food ad libitum and injected. To determine if the conditions used by Weeks et al., (Radiat. Res. 4, 339-347, 1956) were responsible for the increased gut absorption of /sup 239/Pu(VI), relative to Pu(IV), both fasted and unfasted rats were gavaged with acid solutions of /sup 239/Pu(VI) nitrate, in the presence or absence of the holding oxidant (K/sub 2/Cr/sub 2/O/sub 7/). The results indicated that the combination of dichromate and fasting increased absorption about 26-fold.

Research Organization:
Pacific Northwest Lab., Richland, WA
OSTI ID:
5673871
Journal Information:
Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 80:1; ISSN RAREA
Country of Publication:
United States
Language:
English

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Related Subjects

560172* -- Radiation Effects-- Nuclide Kinetics & Toxicology-- Animals-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACTINIDE COMPOUNDS
ACTINIDE ISOTOPES
ACTINIDE NUCLEI
ALPHA DECAY RADIOISOTOPES
ANIMALS
COMPARATIVE EVALUATIONS
DATA
DATA FORMS
DIGESTIVE SYSTEM
EVEN-EVEN NUCLEI
EVEN-ODD NUCLEI
EXPERIMENTAL DATA
FASTING
GASTROINTESTINAL TRACT
GUINEA PIGS
HEAVY NUCLEI
INFORMATION
INJECTION
INTAKE
INTESTINAL ABSORPTION
ISOLATED VALUES
ISOTOPES
MAMMALS
NITRATES
NITROGEN COMPOUNDS
NUCLEI
NUMERICAL DATA
ORAL ADMINISTRATION
OXIDIZERS
OXYGEN COMPOUNDS
PLUTONIUM 238
PLUTONIUM 239
PLUTONIUM COMPOUNDS
PLUTONIUM ISOTOPES
PLUTONIUM NITRATES
RADIOISOTOPES
RADIONUCLIDE KINETICS
RATS
REDOX POTENTIAL
RESPONSE MODIFYING FACTORS
RODENTS
TRANSURANIUM COMPOUNDS
UPTAKE
VERTEBRATES
YEARS LIVING RADIOISOTOPES