The effect of x rays, DTPA, and aspirin on the absorption of plutonium from the gastrointestinal tract of rats

Journal Article · Fri Apr 01 04:00:00 EST 1983 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3575866· OSTI ID:5504545

Sullivan, M F; Gorham, L S; Miller, B M

To measure the effect of radiation on plutonium transport, rats that were exposed to 250-kVp X rays were given /sup 238/Pu 3 days afterwards by either gavage or injection into a ligated segment of the duodenum. In a second group of experiments, rats were either injected intraduodenally with /sup 238/Pu-DTPA or administered the chelate intravenously and the /sup 238/Pu by gavage. In a third experiment, rats that had been gavaged with 200 or 400 mg/kg/day of aspirin for 2 days were injected intragastrically with /sup 238/Pu nitrate. Results of the first experiment showed a dose-dependent increase in /sup 238/Pu absorption between 800 and 1500 rad of lower-body X irradiation. Intravenous or intraduodenal injections of DTPA caused a marked increase in /sup 238/Pu absorption but resulted in decreased plutonium deposition in the skeleton and liver. Retention of /sup 238/Pu in the skeleton of rats given aspirin was double that of controls, but the effect on plutonium absorption was less marked than that of DTPA.

• Research Organization: Pacific Northwest Lab., Richland, WA
• DOE Contract Number: AC06-76RL01830
• OSTI ID: 5504545
• Journal Information: Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 94:1; ISSN RAREA
• Country of Publication: United States
• Language: English

Related Subjects

560162* -- Radionuclide Effects
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& Toxicology-- Animals
Plants
Microorganisms
& Cells
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ABSORPTION
ACETYLSALICYLIC ACID
ACTINIDE COMPOUNDS
ACTINIDE ISOTOPES
ACTINIDE NUCLEI
ALPHA DECAY RADIOISOTOPES
AMINO ACIDS
ANALGESICS
ANIMALS
ANTIPYRETICS
BODY
CARBOXYLIC ACIDS
CENTRAL NERVOUS SYSTEM DEPRESSANTS
CHELATING AGENTS
DIGESTIVE SYSTEM
DRUGS
DTPA
ELECTROMAGNETIC RADIATION
EVEN-EVEN NUCLEI
GASTROINTESTINAL TRACT
GLANDS
HEAVY NUCLEI
HYDROXY ACIDS
INTESTINAL ABSORPTION
IONIZING RADIATIONS
ISOTOPES
LIVER
MAMMALS
NITRATES
NITROGEN COMPOUNDS
NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
OXYGEN COMPOUNDS
PLUTONIUM 238
PLUTONIUM COMPOUNDS
PLUTONIUM ISOTOPES
PLUTONIUM NITRATES
RADIATIONS
RADIOISOTOPES
RADIOPROTECTIVE SUBSTANCES
RADIOSENSITIVITY EFFECTS
RATS
RODENTS
SKELETON
TRANSURANIUM COMPOUNDS
UPTAKE
VERTEBRATES
X RADIATION
YEARS LIVING RADIOISOTOPES