Effectiveness of DTPA therapy when administered intragastrically or intraperitoneally to remove Pu from adult or neonatal rats

Journal Article · Fri Oct 31 23:00:00 EST 1986 · Health Phys.; (United States)

DOI:https://doi.org/10.1097/00004032-198611000-00007· OSTI ID:6846809

Sullivan, M F; Ruemmler, P S

Adult and neonatal rats were given /sup 238/Pu by gavage or parenterally and treated with 0.5 mmoles/kg of calcium diethylenetriaminepentaacetate (DTPA), by gavage or parenterally, to determine its effectiveness for removing Pu. Parenteral administration of DTPA to adult rats 2 h after an intravenous /sup 238/Pu injection was much more effective than intragastric treatment, removing nearly 70% of the retained dose. When /sup 238/Pu was given to adults intragastrically (IG), followed by DTPA given either intraperitoneally (IP) or IG 2 h later, /sup 238/Pu absorption increased while retention remained either unchanged, or increased. When neonates were given /sup 238/Pu IG and treated 2 h later with intraperitoneal or intragastric DTPA, removal of /sup 238/Pu was better than in adults: more than 80% of the /sup 238/Pu that was absorbed and retained was removed by intragastric DTPA. When neonates were injected IP with /sup 238/Pu, treatment with intraperitoneal DTPA was more effective for /sup 238/Pu removal than intragastric treatment.

• Research Organization: Pacific Northwest Lab., Richland, WA
• OSTI ID: 6846809
• Journal Information: Health Phys.; (United States), Journal Name: Health Phys.; (United States) Vol. 5; ISSN HLTPA
• Country of Publication: United States
• Language: English

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560162* -- Radionuclide Effects
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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACTINIDE ISOTOPES
ACTINIDE NUCLEI
ALPHA DECAY RADIOISOTOPES
AMINO ACIDS
ANIMALS
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DIGESTIVE SYSTEM
DRUGS
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EVEN-EVEN NUCLEI
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GASTROINTESTINAL TRACT
HEAVY NUCLEI
ISOTOPES
MAMMALS
NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PLUTONIUM 238
PLUTONIUM ISOTOPES
RADIOISOTOPES
RADIOPROTECTIVE SUBSTANCES
RATS
REMOVAL
RETENTION
RODENTS
STOMACH
VERTEBRATES
YEARS LIVING RADIOISOTOPES