Differential plasma catecholamine and neuropeptide Y responses to acute stress in rats
Neuropeptide Y (NPY) is a vasoconstrictor present in the sympatho-adrenomedullary system and may be co-released with norepinephrine (NE) and epinephrine (EPI) during sympathetic activation. The authors studied plasma NPY-immunoreactivity (-ir, radioimmunoassay) and catecholamine (radioenzymatic) responses during two acute stress paradigms that differ in character, intensity, and duration. The intermittent stress of footshock evoked intensity-dependent immediate increments in plasma NE and EPI, and a delayed NPY-ir response. Prolonged immobilization caused greater increases in plasma NE and EPI levels and no changes in plasma NPY-ir until the end of the stress session. Plasma NPY-ir responses correlated with those of NE but not with EPI suggesting a sympathetic origin for the release of the peptide. Relatively greater NPY-ir responses to footshock than to immobilization may be consistent with a preferential release of the peptide by a bursting but not continuous mode of sympathetic activation. However, it may also be due to a differential activation of the sympathetic nerves and adrenal medulla by these two stress situations.
- Research Organization:
- Georgetown Univ., Washington, DC (USA)
- OSTI ID:
- 5298900
- Journal Information:
- Life Sci.; (United States), Vol. 42:17
- Country of Publication:
- United States
- Language:
- English
Similar Records
Release of NPY in pig pancreas: Dual parasympathetic and sympathetic regulation
Neuropeptide Y administration acutely increases hypothalamic corticotropin-releasing factor immunoreactivity: lack of effect in other rat brain regions
Related Subjects
AUTONOMIC NERVOUS SYSTEM
BIOLOGICAL STRESS
CATECHOLAMINES
SECRETION
PEPTIDES
ADRENALINE
NORADRENALINE
RADIOENZYMATIC ASSAY
RADIOIMMUNOASSAY
RATS
VASOCONSTRICTORS
ADRENAL HORMONES
AMINES
ANIMALS
AROMATICS
AUTONOMIC NERVOUS SYSTEM AGENTS
CARDIOTONICS
CARDIOVASCULAR AGENTS
DRUGS
HORMONES
HYDROXY COMPOUNDS
IMMUNOASSAY
IMMUNOLOGY
ISOTOPE APPLICATIONS
MAMMALS
NERVOUS SYSTEM
NEUROREGULATORS
ORGANIC COMPOUNDS
PHENOLS
POLYPHENOLS
PROTEINS
RADIOASSAY
RADIOIMMUNOLOGY
RODENTS
STEROID HORMONES
SYMPATHOMIMETICS
TRACER TECHNIQUES
VERTEBRATES
550201* - Biochemistry- Tracer Techniques