Histopathological observations in the canine prostate treated by local microwave hyperthermia
A large series of repeated experiments were performed applying localized microwave hyperthermia to the prostate in dogs using a new water-cooled skirt-type antenna (1), operating at 915 MHz, as part of a new hyperthermia apparatus being developed for the treatment of the prostate in humans. The prostate gland of 20 male dogs was heated repeatedly under general anesthesia, at temperatures between 40/sup 0/C and 47/sup 0/C, and for different lengths of time up to 10 h. The prostate and other tissues were evaluated histopathologically following treatments. Invariably, all treatments by hyperthermia of the prostate caused a mononuclear inflammatory infiltration in the interstitium and polymorphonuclear infiltration in the glandular elements. Permanent tissue damage was found to be time-and temperature-dependent. Heating at 42.5/sup 0/C (+/- 0.5/sup 0/5C) for up to 1.5 h was found to be harmless and could be safely repeated with our equipment. This study was part of a preclinical evaluation of a new antenna and apparatus.
- Research Organization:
- Beilinson Medical Center, Petach Tiqva, Israel
- OSTI ID:
- 5268628
- Journal Information:
- Prostate (N.Y.); (United States), Vol. 1
- Country of Publication:
- United States
- Language:
- English
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560205* - Thermal Effects- Vertebrates- (-1987)