Clinical experiences with local microwave hyperthermia

Conference · Fri May 01 04:00:00 EDT 1981 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

OSTI ID:6195077

Luk, K H; Purser, P R; Castro, J R; Meyler, T S; Phillips, T L

At the Claire Zellerbach Saroni Tumor Institute, Mount Zion Hospital and Medical Center, 38 patients who failed definitive radiotherapy and chemotherapy were treated with 915 megahertz and 2450 megahertz microwave hyperthermia to observe normal tissue tolerance and therapeutic responses. When hyperthermia was combined with radiation, complete clinical regression occurred in 41% of patients and partial regression in 37%, however with hyperthermia alone, complete regression occurred in 18% of patients and partial regression in 18%. Thus, moderate local tumor hyperthermia (42.5/sup 0/C) following low dose irradiation (1800 to 2700 rad) has resulted in significant responses in recurrent tumors in previously irradiated areas. Thermal dosimetry remained an outstanding problem for clinical hyperthermia, in part because of inadequacy of heat delivery and measurement systems, and in part because of patient variations in terms of tolerance to heat and tumor physiological changes with fractions of hyperthermia. Side effects of thermal blistering and burns were correlated with maximum temperatures attained during heat treatments.

• Research Organization: Univ. of California, San Francisco
• OSTI ID: 6195077
• Conference Information: Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Journal Volume: 7:5
• Country of Publication: United States
• Language: English

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62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ARMS
BEAMS
BIOLOGICAL EFFECTS
BODY
BODY AREAS
BODY TEMPERATURE
BURNS
DISEASES
ELECTROMAGNETIC RADIATION
ELECTRON BEAMS
ELEMENTARY PARTICLES
HYPERTHERMIA
INJURIES
LEGS
LEPTON BEAMS
LIMBS
MASSLESS PARTICLES
MEDICINE
MICROWAVE RADIATION
NECK
NEOPLASMS
NUCLEAR MEDICINE
ORGANS
PARTICLE BEAMS
PATIENTS
PHOTONS
RADIATIONS
RADIOLOGY
RADIOTHERAPY
SKIN
THERAPY