Hyperthermia in cancer therapy

Journal Article · Sat Mar 01 04:00:00 EST 1980 · West. J. Med.; (United States)

OSTI ID:5436189

Luk, K H

Many malignant cell lines exhibit a therapeutic response to supernormal temperatures. Selective destruction of tumor cells has been observed following moderate hyperthermia (42/sup 0/ to 43/sup 0/C) in vivo, and tumor eradication by heat has been achieved without normal tissue morbidity. Thermal cell killing appears to be independent of oxygen tension, and the sensitivity of S-phase cells to thermal damage is complementary to that for cellular radiation response. Hyperthermia is therefore a promising adjunct to radiotherapy. At the Claire Zellerbach Saroni Tumor Institute, Mount Zion Hospital and Medical Center, San Francisco, the differential thermal sensitivity of malignant cells is being studied to achieve improved tumor control in patients refractory to more conventional treatments. Preliminary results of a two-year clinical trial indicated increased local objective responses when hyperthermia and radiation were used in combination.

• OSTI ID: 5436189
• Journal Information: West. J. Med.; (United States), Journal Name: West. J. Med.; (United States) Vol. 132:3; ISSN WJMDA
• Country of Publication: United States
• Language: English

Related Subjects

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62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
BODY TEMPERATURE
CELL KILLING
DISEASES
HYPERTHERMIA
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
PATIENTS
RADIOLOGY
RADIOTHERAPY
SYNERGISM
THERAPY
TUMOR CELLS