Hyperthermia in combination with radiotherapy: a review of five years experience in the treatment of superficial tumors
Facilities for regional tumor hyperthermia has been in use at RPMI since 1976, and have been routinely used to treat patients according to protocol since 1977. Hyperthermia delivery has been exclusively by microwave using 434 MHz, 915 MHz and 2450 MHz. Approximately 125 patients have been treated and 70 have achieved completion of therapy and follow-up. Follow-up has been at least one month and several patients have been followed for one to two years. Initially, for entry into the hyperthermia protocol, patients were required to have three or more lesions. One lesion on each patient was treated with 800 rad fractions repeated three times on a 72 hour schedule. The second lesion was treated with 700 rad fractions and the third with 500 rad plus hyperthermia on the same schedule. Twelve patients with multiple melanoma lesions completed this study. Of eight patients who survived three months, all lesions treated by hyperthermia plus radiotherapy responded completely, while only five lesions treated by radiotherapy alone so responded. In a second study, 58 patients with superficial tumors were treated by a protocol where hyperthermia was added to optimal conventional radiotherapy. Of the total, 43 patients had complete tumor response at follow-up varying from one month to 18 month. None of the lesions treated with hyperthermia responded less well than those treated by radiotherapy alone. Morbidity, as measured by skin reaction, was rarely increased in the heated field.
- Research Organization:
- Roswell Park Memorial Inst., Buffallo, NY
- OSTI ID:
- 5377173
- Journal Information:
- Int. J. Radiat. Oncol., Biol. Phys.; (United States), Vol. 9:9
- Country of Publication:
- United States
- Language:
- English
Similar Records
Hyperthermia and radiation in combination: a clinical fractionation regime
Tumor control and therapeutic gain with different schedules of combined radiotherapy and local external hyperthermia in human cancer
Related Subjects
62 RADIOLOGY AND NUCLEAR MEDICINE
HYPERTHERMIA
RADIOSENSITIVITY EFFECTS
SIDE EFFECTS
RADIOTHERAPY
SKIN
BIOLOGICAL RADIATION EFFECTS
MELANOMAS
MICROWAVE RADIATION
BIOLOGICAL EFFECTS
BODY
BODY TEMPERATURE
DISEASES
ELECTROMAGNETIC RADIATION
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
ORGANS
RADIATION EFFECTS
RADIATIONS
RADIOLOGY
THERAPY
560151* - Radiation Effects on Animals- Man
560206 - Thermal Effects- Man- (-1987)
550603 - Medicine- External Radiation in Therapy- (1980-)