Hyperthermia and radiation in combination: a clinical fractionation regime

Journal Article · Tue Jul 01 04:00:00 EDT 1980 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

DOI:https://doi.org/10.1016/0360-3016(80)90325-9· OSTI ID:6792430

Bicher, H I; Sandhu, T S; Hetzel, F W

A fractionation regime has been devised and clinically tested to use a combination of hyperthermia and low dose radiation therapy to treat tumors with a curative intent. Hyperthermia is included using microwaves delivered to a defined tissue volume through specially designed applicators. Frequencies of 2450, 915, or 300 MHz are used according to the desired penetration depth. Each treatment lasts for 90 minutes. The skin is cooled by an air jet. Tissue temperature is kept at 45/sup 0/C when hyperthermia alone is used and 42/sup 0/C in combination with radiation. Patients are treated twice a week with 72 hour intervals between treatments. The regime consists of 4 treatments of hyperthermia alone followed by a week of rest. Thereafter each hyperthermia treatment is preceded by a 400 rad fraction of x-irradiation delivered in 4 combined treatments to a total of 1600 rad. This low total radiation dose allows retreatment of previously irradiated areas or organs. No toxicity induced by this combination has been detected, even in areas previously radiated to high doses. Twenty-three patients have been entered into the protocol that encompasses 37 treatment fields. Most tumors respond to treatment, many of these with total disappearance; skin, brain, breast, and spinal cord are among the treated areas. Melanomas and lymphomas are the most sensitive tumors, sarcomas the most resistant; adeno and squamous cell carcinoma in between.

• Research Organization: Henry Ford Hospital, Detroit, MI
• OSTI ID: 6792430
• Journal Information: Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 6:7; ISSN IOBPD
• Country of Publication: United States
• Language: English

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62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BODY TEMPERATURE
BRAIN
CARCINOMAS
CENTRAL NERVOUS SYSTEM
DISEASES
DOSES
ELECTROMAGNETIC RADIATION
EXTERNAL IRRADIATION
FRACTIONATED IRRADIATION
GLANDS
HYPERTHERMIA
IONIZING RADIATIONS
IRRADIATION
LOW DOSE IRRADIATION
LYMPHOMAS
MAMMARY GLANDS
MELANOMAS
MICROWAVE RADIATION
NEOPLASMS
NERVOUS SYSTEM
ORGANS
PATIENTS
RADIATION DOSES
RADIATION EFFECTS
RADIATIONS
RADIOSENSITIVITY
RADIOSENSITIVITY EFFECTS
SARCOMAS
SKIN
SPINAL CORD
X RADIATION