Microwave-induced local hyperthermia in combination with radiotherapy of human malignant tumors

Conference · Fri Feb 15 04:00:00 EST 1980 · Cancer; (United States)

OSTI ID:5644680

U, R; Noell, K T; Woodward, K T; Worde, B T; Fishburn, R I; Miller, L S

Since 1976, two groups of patients have been treated with local microwave hyperthermia immediately following ionizing radiation. Group A patients had measurable multiple lesions assigned radiotherapy only, microwave hyperthermia only, or combined treatment. Ionizing radiation in 200 to 600 rad fractions was used 2 to 5 times per week to a total of 1800 to 4200 rad in 5 to 14 fractions. Group B patients had combination treatment only, with radiation fractions of 200 to 600 rad 2 to 5 times per week to a total of 200 to 4800 rad total in 6 to 20 fractions. Both groups received hyperthermia (42 to 44 C) 2 to 3 times per week, maximum ten sessions in four weeks. The 19 patients treated have had squamous cell carcinoma, adenocarcinoma, malignant melanoma, plasmacytoma, epithelioid sarcoma, and undifferentiated carcinoma. After more than 150 hyperthermia sessions, we find: (1) local hyperthermia with microwave alone or in combination with ionizing radiation can be used with excellent normal tissue tolerance provided local tissue temperatures are carefully monitored and controlled; (2) a higher level of heat induction in tumor tissue as compared to surrounding normal tissues; and (3) repeated hyperthermia at 42 to 43.5 C for 45 minutes per session immediately following photon irradiation yields a favorable therapeutic result, occasionally dramatic. Local microwave hyperthermia in combination withradiotherapy offers the possibility of substantial impact on clinical cancer therapy, whether of curative or palliative intent.

• Research Organization: Veterans Administration Medical Center, Durham, NC
• OSTI ID: 5644680
• Conference Information: Journal Name: Cancer; (United States) Journal Volume: 45:4
• Country of Publication: United States
• Language: English

Related Subjects

550603* -- Medicine-- External Radiation in Therapy-- (1980-)
560151 -- Radiation Effects on Animals-- Man
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY TEMPERATURE
COBALT 60
COBALT ISOTOPES
DATA
DATA COMPILATION
DATA FORMS
DISEASES
ELECTROMAGNETIC RADIATION
ELECTRONS
ELEMENTARY PARTICLES
FERMIONS
FRACTIONATED IRRADIATION
GAMMA RADIATION
HYPERTHERMIA
INFORMATION
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IONIZING RADIATIONS
IRRADIATION
ISOLATED VALUES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LEPTONS
LOCAL IRRADIATION
MEDICINE
MICROWAVE RADIATION
MINUTES LIVING RADIOISOTOPES
NEOPLASMS
NUCLEAR MEDICINE
NUCLEI
NUMERICAL DATA
ODD-ODD NUCLEI
PATIENTS
RADIATIONS
RADIOISOTOPES
RADIOLOGY
RADIOSENSITIVITY
RADIOSENSITIVITY EFFECTS
RADIOTHERAPY
SIDE EFFECTS
TEMPERATURE MEASUREMENT
THERAPY
TUMOR CELLS
X RADIATION
YEARS LIVING RADIOISOTOPES