Histopathological and biochemical effects of intraoperative interstitial radiofrequency-induced hyperthermia and intraoperative electron radiation, alone and in combination, on normal canine liver tissue
Thesis/Dissertation
·
OSTI ID:5668783
Acute and chronic histopathologic and biochemical effects on normal canine liver tissue from a single intraoperative application of heat and radiation, heat alone, and radiation alone have been evaluated in 54 adult mongrel dogs. The tolerance of normal canine liver tissue to single doses of intraoperative radiation therapy (IORT) was evaluated at doses of 5, 10, 20, 30, and 40 Gy. In addition, intraoperative interstitial hyperthermia (43{degree}C, 60 minutes, 500 kHz) was applied alone and in combination with a single intraoperative dose of 30 Gy from an 18 MeV electron beam. Blood flow at the center of the implantation site before, during and after hyperthermia treatments was also evaluated.
- Research Organization:
- Medical Coll. of Ohio, Toledo, OH (USA)
- OSTI ID:
- 5668783
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560152* -- Radiation Effects on Animals-- Animals
560400 -- Other Environmental Pollutant Effects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BEAMS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BLOOD FLOW
BODY
BODY TEMPERATURE
DIGESTIVE SYSTEM
DOGS
DOSE-RESPONSE RELATIONSHIPS
ELECTROMAGNETIC RADIATION
ELECTRON BEAMS
GLANDS
HYPERTHERMIA
LEPTON BEAMS
LIVER
MAMMALS
ORGANS
PARTICLE BEAMS
RADIATION EFFECTS
RADIATIONS
RADIOSENSITIVITY EFFECTS
RADIOWAVE RADIATION
VERTEBRATES
560400 -- Other Environmental Pollutant Effects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BEAMS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BLOOD FLOW
BODY
BODY TEMPERATURE
DIGESTIVE SYSTEM
DOGS
DOSE-RESPONSE RELATIONSHIPS
ELECTROMAGNETIC RADIATION
ELECTRON BEAMS
GLANDS
HYPERTHERMIA
LEPTON BEAMS
LIVER
MAMMALS
ORGANS
PARTICLE BEAMS
RADIATION EFFECTS
RADIATIONS
RADIOSENSITIVITY EFFECTS
RADIOWAVE RADIATION
VERTEBRATES