Intraoperative radiation therapy-induced sarcomas in dogs

Journal Article · Fri Dec 01 04:00:00 EST 1989 · Radiation Research; (USA)

DOI:https://doi.org/10.2307/3577800· OSTI ID:5017188

Hoekstra, H J; Sindelar, W F; Kinsella, T J; Mehta, D M ^[1]

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1. Groningen Univ. Hospital (Netherlands)

In a canine model the tolerance of normal and surgically manipulated tissue to intraoperative radiotherapy (IORT) was investigated to provide guidelines for the clinical use of IORT in human cancer patients. A dose of 20 Gy IORT, with or without external beam radiotherapy, was generally well tolerated without significant increased treatment morbidity. Higher doses of IORT (over 30 Gy) have produced radiation-induced sarcomas in some animals followed over a long period. Therefore IORT should be used only in human cancer patients in well controlled studies, in which complications are well documented, and the possibility of radiation-induced malignancies in long-term survival should be considered.

• OSTI ID: 5017188
• Journal Information: Radiation Research; (USA), Journal Name: Radiation Research; (USA) Vol. 120:3; ISSN RAREA; ISSN 0033-7587
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL MODELS
DISEASES
DOGS
DOSES
EXPERIMENTAL NEOPLASMS
MAMMALS
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
RADIATION DOSES
RADIOINDUCTION
RADIOLOGY
RADIOTHERAPY
SARCOMAS
SIDE EFFECTS
THERAPY
VERTEBRATES