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Title: Tissue tolerance of normal and surgically manipulated canine liver to intraoperative radiation therapy (IORT)

Abstract

The purpose of the study is to obtain dose guidelines for the delivery of intraoperative radiotherapy to the liver of patients with colorectal liver metastases. Following partial resection of the liver, a single high dose of 10, 20, 25, and 30 Gy intraoperative radiotherapy was applied to both the resection plane as well as a nonsurgically manipulated part of the liver of 25 beagles. The temporal sequence of histological and ultrastructural changes of these irradiated parts of the liver tissue was investigated. The feasibility of delivering a single large dose of intraoperative electron beam radiotherapy to the normal and partially hepatectomized liver was experimentally investigated in a canine study. There were no postoperative complications, no morbidity or mortality with a minimal follow-up of 1 year. Autopsy performed 3 months following irradiation showed only mild histopathological changes. One year following intraoperative radiotherapy more distinct histopathological changes consisting of capsular thickening, diffuse parenchymal fibrosis and subcapsular hepatocellular atrophy were found. The liver function remained intact. This study demonstrated that intraoperative radiotherapy to part of the liver in the canine model can be safely applied and doses up to 30 Gy are well tolerated. 34 refs., 6 figs., 1 tab.

Authors:
; ; ; ;  [1];  [2]
  1. (Univ. Hospital, Groningen (Netherlands))
  2. (Groningen State Univ. (Netherlands))
Publication Date:
OSTI Identifier:
6568813
Resource Type:
Journal Article
Resource Relation:
Journal Name: International Journal of Radiation Oncology, Biology and Physics; (United States); Journal Volume: 27:5
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; LIVER; BIOLOGICAL RADIATION EFFECTS; SURGERY; RADIOTHERAPY; SIDE EFFECTS; BIOLOGICAL MODELS; BIOLOGICAL EFFECTS; BODY; DIGESTIVE SYSTEM; GLANDS; MEDICINE; NUCLEAR MEDICINE; ORGANS; RADIATION EFFECTS; RADIOLOGY; THERAPY; 560152* - Radiation Effects on Animals- Animals

Citation Formats

Chromheecke, M., Oldhoff, J., Hoekstra, H.J., Vermeij, J., Grond, A.J.K., and Konings, A.W.T.. Tissue tolerance of normal and surgically manipulated canine liver to intraoperative radiation therapy (IORT). United States: N. p., 1993. Web. doi:10.1016/0360-3016(93)90535-4.
Chromheecke, M., Oldhoff, J., Hoekstra, H.J., Vermeij, J., Grond, A.J.K., & Konings, A.W.T.. Tissue tolerance of normal and surgically manipulated canine liver to intraoperative radiation therapy (IORT). United States. doi:10.1016/0360-3016(93)90535-4.
Chromheecke, M., Oldhoff, J., Hoekstra, H.J., Vermeij, J., Grond, A.J.K., and Konings, A.W.T.. Wed . "Tissue tolerance of normal and surgically manipulated canine liver to intraoperative radiation therapy (IORT)". United States. doi:10.1016/0360-3016(93)90535-4.
@article{osti_6568813,
title = {Tissue tolerance of normal and surgically manipulated canine liver to intraoperative radiation therapy (IORT)},
author = {Chromheecke, M. and Oldhoff, J. and Hoekstra, H.J. and Vermeij, J. and Grond, A.J.K. and Konings, A.W.T.},
abstractNote = {The purpose of the study is to obtain dose guidelines for the delivery of intraoperative radiotherapy to the liver of patients with colorectal liver metastases. Following partial resection of the liver, a single high dose of 10, 20, 25, and 30 Gy intraoperative radiotherapy was applied to both the resection plane as well as a nonsurgically manipulated part of the liver of 25 beagles. The temporal sequence of histological and ultrastructural changes of these irradiated parts of the liver tissue was investigated. The feasibility of delivering a single large dose of intraoperative electron beam radiotherapy to the normal and partially hepatectomized liver was experimentally investigated in a canine study. There were no postoperative complications, no morbidity or mortality with a minimal follow-up of 1 year. Autopsy performed 3 months following irradiation showed only mild histopathological changes. One year following intraoperative radiotherapy more distinct histopathological changes consisting of capsular thickening, diffuse parenchymal fibrosis and subcapsular hepatocellular atrophy were found. The liver function remained intact. This study demonstrated that intraoperative radiotherapy to part of the liver in the canine model can be safely applied and doses up to 30 Gy are well tolerated. 34 refs., 6 figs., 1 tab.},
doi = {10.1016/0360-3016(93)90535-4},
journal = {International Journal of Radiation Oncology, Biology and Physics; (United States)},
number = ,
volume = 27:5,
place = {United States},
year = {Wed Dec 01 00:00:00 EST 1993},
month = {Wed Dec 01 00:00:00 EST 1993}
}