Audiogenic seizures and cochlear damage in rats after perinatal antithyroid treatment

Journal Article · Sun Jun 01 00:00:00 EDT 1980 · Endocrinology; (United States)

DOI:https://doi.org/10.1210/endo-106-6-1686· OSTI ID:5245199

Van Milllesworth, L; Norris, C H

The feeding of goitrogens during pregnancy and lactation causes the offspring of rats to be partially deaf and persistently sensitive to audiogenic seizures. The most potent goitrogen, propylthiouracil, caused severe dysfunction and disorganization of the organ of Corti. Adult seizure-susceptible rats showed increased sensitivity to audiogenic seizures when they were fed propylthiouracil.

• Research Organization: Univ. of Tennessee Center for the Health Sciences, Memphis
• DOE Contract Number: DE-AS05-76EV01643
• OSTI ID: 5245199
• Journal Information: Endocrinology; (United States), Vol. 106:6
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
ANTITHYROID DRUGS
BIOLOGICAL EFFECTS
AUDITORY ORGANS
PATHOLOGICAL CHANGES
FETUSES
SENSITIVITY
NEONATES
NERVOUS SYSTEM
LACTATION
RATS
SOUND WAVES
ANIMALS
BODY
DISEASES
DRUGS
MAMMALS
ORGANS
RODENTS
SENSE ORGANS
VERTEBRATES
551000* - Physiological Systems
550900 - Pathology
550100 - Behavioral Biology