EFFECTS OF PRENATAL X-RAY IRRADIATION ON AUDIOGENIC SEIZURES IN THE RAT

Journal Article · Fri Sep 01 04:00:00 EDT 1961 · Experimental Neurology (U.S.)

DOI:https://doi.org/10.1016/0014-4886(61)90040-1· OSTI ID:4776460

Werboff, J; Broeder, J D; Havlena, J; Sikov, M R

Gravid albino rats of the Sprague-Dawley strain received 25, 50, or 100 r whole-body x irradiation on days 5, 10, 15, or 20 of gestation. Controls were sham-irradiated. Over 500 surviving offspring were evaluated for susceptibility to audiogenic seizures under two conditions of threshold testing, with the bell alone and with a pretreatment of Metrazol (l6 mg/kg). the tests were conducted when the animals were 120 and l22 days of age. Irradiation on days 5 or 10 of gestition resulted in a decrease in seizure responses, while irridiation on days 15 or 20 oE gestation resulted in an incresse in seizure responses. The differences were more pronounced under the lowered threshold condition. These findings appeared to be independent of dosage. It was concluded that low levels of prenatal irradiation can alter the threshold of susceptibility to audiogenic seizeres in the offspring. (auth)

• Research Organization: Wayne State Univ., Detroit
• NSA Number: NSA-17-001288
• OSTI ID: 4776460
• Journal Information: Experimental Neurology (U.S.), Journal Name: Experimental Neurology (U.S.) Vol. Vol: 4; ISSN EXNEA
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

AGE
AUDIOGENIC SEIZURES
BIOLOGY AND MEDICINE
BODY
BRAIN
DISEASES
DRUGS
EPILEPSY
FETUSES
GENETICS
MEASURED VALUES
NERVOUS SYSTEM
PREGNANCY
QUANTITY RATIO
RADIATION DOSES
RATS
SOUND
TESTING
X RADIATION