Absorption, metabolism and clearance of {sup 14}C atrazine in rhesus monkey and man following intravenous or dermal administration
- UCSF, San Francisco (United States); and others
Dermal exposure of field workers to pesticides is generally determined by measuring the amount of active ingredient (ai) on body patches; the dermal load is expressed as mg.cm{sup 2}/lb. ai handled/day. In the absence of human data, the internal daily dose is calculated for risk characterization assumes either 100% penetration or uses the dermal penetration factor established in the rat. For atrazine, a corn herbicide used extensively in the mid-western U.S., percutaneous absorption values range from 6% in human (in vitro) to 27% in rat (in vitro). The objective if this study was to determine the in vitro percutaneous absorption, metabolism and elimination of {sup 14}C-atrazone in man. A preliminary [{sup 14}C] atrazine study in female rhesus monkeys (iv)established that the disposition of atrazine followed a two compartment model (t 1/2 a=1.5 hr; t 1/2 {beta}=17.7 hr.) with a 44.3% {sup 14}C-residues appearing in urine by 12 hours, 84.8% by 168 hours; total recovery was 98.9 {+-} 5.9% by day 7. Atrazine and its chlortriazine metabolites accounted for approximately 15-20 % of the administered dose and the mercapture of atrazine accounted for an additional 15-20%; the remainder of the dose was identified polar metabolites. Six humans were dermally exposed to {sup 14}C-atrazine for 24 hours at levels of 0.2 or 2.0 mg diluted as an end-use spray. Data on absorption, metabolism and clearance of atrazine in man will be presented.
- OSTI ID:
- 369970
- Report Number(s):
- CONF-960376-; TRN: 96:003805-0017
- Resource Relation:
- Conference: Spring national meeting of the American Chemical Society (ACS), New Orleans, LA (United States), 24-28 Mar 1996; Other Information: PBD: 1996; Related Information: Is Part Of 211th ACS national meeting; PB: 2284 p.
- Country of Publication:
- United States
- Language:
- English
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