Effect of DEET (N,N-diethyl-m-toluamide) on dermal persistence and absorption of the insecticide fenitrothion in rats and monkeys

Journal Article · Thu Jan 01 04:00:00 EST 1987 · J. Toxicol. Environ. Health; (United States)

DOI:https://doi.org/10.1080/15287398709531086· OSTI ID:5347245

Moody, R P; Riedel, D; Ritter, L; Franklin, C A

The in vitro persistence of /sup 14/C-ring-labeled fenitrothion in acetone (F-A) or N,N-diethyl-m-toluamide (DEET) (F-D) vehicles was determined, and in vivo studies were conducted to determine the persistence and absorption of (/sup 14/C)fenitrothion in acetone or DEET applied to the skin of rats and rhesus monkeys. In vitro persistence of (/sup 14/C)fenitrothion was significantly enhanced in DEET vehicle, and the percent residual /sup 14/C activity at 24 h was positively correlated with the amount (micrograms) of DEET employed (e.g., in vitro, 98.6 +/- 1.7% /sup 14/C recovery after 24 h with (/sup 14/C)fenitrothion in DEET versus 1.9 +/- 0.3% without DEET). Significantly greater (p less than 0.05) fenitrothion /sup 14/C activity was detected in skin swabs taken after 24 h at the dose site with DEET vehicle from rats (acetone (F-A): 15.0 +/- 5.8%; DEET (F-D): 31.5 +/- 3.9%)) and monkeys (F-A: 3.2 +/- 1.5%; F-D: 9.7 +/- 6.0%). A lag in the urinary excretion kinetics was observed for F-D in comparison with F-A for both rats and monkeys. The total percent urinary 14C recovery was significantly higher in rats dosed with F-A (73.0 +/- 7.4%) than with F-D (52.4 +/- 8.8%) but not in monkeys (F-A: 34.7 +/- 7.1%; F-D: 36.7 +/- 2.9%). The observed species-related differences are discussed in context with the use of animal models for predicting dermal penetration of pesticides in humans.

• Research Organization: Environmental Health Centre, Ottawa, Ontario
• OSTI ID: 5347245
• Journal Information: J. Toxicol. Environ. Health; (United States), Journal Name: J. Toxicol. Environ. Health; (United States) Vol. 22:4; ISSN JTEHD
• Country of Publication: United States
• Language: English

Related Subjects

550501 -- Metabolism-- Tracer Techniques
560300* -- Chemicals Metabolism & Toxicology
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ABSORPTION
AMIDES
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL MODELS
BIOLOGICAL VARIABILITY
CARBON 14 COMPOUNDS
GENETIC VARIABILITY
INSECTICIDES
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
MAMMALS
MONKEYS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PESTICIDES
PRIMATES
RATS
RODENTS
SKIN ABSORPTION
TRACER TECHNIQUES
UPTAKE
VERTEBRATES