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Title: Differential therapeutic responses of thiol compounds in the reversal of methylmercury inhibited acid phosphatase and cathepsin E in the central nervous system of rat

Abstract

Though considerable headway has been made in elucidating the effect of methylmercury on the biochemical machinery of nervous system, the studies on the alterations in the levels of acid hydrolases received less attention. Being a lysosomal marker, acid phosphatase is one of the most extensively studies enzymes amongst the acid hydrolases. Its significance in various key physiological as well as pathological processes is well preserved in literature. Cathepsin E, an aspartic proteinase, has been demonstrated in a number of cells and tissues within the human body, rat, E. coli where its role is implicated in a number of important metabolic processes. In the present paper, we report the results of the differential levels of inhibition of these enzymes with methylmercury as well as their differential recoveries with two thiols (N-acetyl-DL-homocysteine thiolactone and glutathione) in various neuroanatomical areas (olfactory bulbs, cerebral hemispheres, cerebellum, medulla oblongata and spinal cord) of rat. 22 refs., 5 figs.

Authors:
; ;  [1]
  1. Saurashtra Univ., Rajkot (India)
Publication Date:
Sponsoring Org.:
USDOE
OSTI Identifier:
35703
Resource Type:
Journal Article
Journal Name:
Bulletin of Environmental Contamination and Toxicology
Additional Journal Information:
Journal Volume: 49; Journal Issue: 1; Other Information: PBD: Jul 1992
Country of Publication:
United States
Language:
English
Subject:
56 BIOLOGY AND MEDICINE, APPLIED STUDIES; 55 BIOLOGY AND MEDICINE, BASIC STUDIES; METHYLMERCURY; BIOLOGICAL EFFECTS; THIOLS; THERAPEUTIC USES; MICE; CENTRAL NERVOUS SYSTEM; ACID PHOSPHATASE; BIOLOGICAL PATHWAYS; CATHEPSINS

Citation Formats

Vinay, S D, Raghu, K G, and Sood, P P. Differential therapeutic responses of thiol compounds in the reversal of methylmercury inhibited acid phosphatase and cathepsin E in the central nervous system of rat. United States: N. p., 1992. Web. doi:10.1007/BF00193344.
Vinay, S D, Raghu, K G, & Sood, P P. Differential therapeutic responses of thiol compounds in the reversal of methylmercury inhibited acid phosphatase and cathepsin E in the central nervous system of rat. United States. https://doi.org/10.1007/BF00193344
Vinay, S D, Raghu, K G, and Sood, P P. 1992. "Differential therapeutic responses of thiol compounds in the reversal of methylmercury inhibited acid phosphatase and cathepsin E in the central nervous system of rat". United States. https://doi.org/10.1007/BF00193344.
@article{osti_35703,
title = {Differential therapeutic responses of thiol compounds in the reversal of methylmercury inhibited acid phosphatase and cathepsin E in the central nervous system of rat},
author = {Vinay, S D and Raghu, K G and Sood, P P},
abstractNote = {Though considerable headway has been made in elucidating the effect of methylmercury on the biochemical machinery of nervous system, the studies on the alterations in the levels of acid hydrolases received less attention. Being a lysosomal marker, acid phosphatase is one of the most extensively studies enzymes amongst the acid hydrolases. Its significance in various key physiological as well as pathological processes is well preserved in literature. Cathepsin E, an aspartic proteinase, has been demonstrated in a number of cells and tissues within the human body, rat, E. coli where its role is implicated in a number of important metabolic processes. In the present paper, we report the results of the differential levels of inhibition of these enzymes with methylmercury as well as their differential recoveries with two thiols (N-acetyl-DL-homocysteine thiolactone and glutathione) in various neuroanatomical areas (olfactory bulbs, cerebral hemispheres, cerebellum, medulla oblongata and spinal cord) of rat. 22 refs., 5 figs.},
doi = {10.1007/BF00193344},
url = {https://www.osti.gov/biblio/35703}, journal = {Bulletin of Environmental Contamination and Toxicology},
number = 1,
volume = 49,
place = {United States},
year = {Wed Jul 01 00:00:00 EDT 1992},
month = {Wed Jul 01 00:00:00 EDT 1992}
}