Normalizing renal reducing ability prevents adriamycin-induced proteinuria

Journal Article · Fri Nov 11 00:00:00 EST 2005 · Biochemical and Biophysical Research Communications

DOI:https://doi.org/10.1016/j.bbrc.2005.08.266· OSTI ID:20713426

Oteki, Takaaki ^[1]; Nagase, Sohji ^[1]; Yokoyama, Hidekatsu ^[2]; Ohya, Hiroaki ^[2]; Akatsuka, Takao ^[2]; Tada, Mika ^[3]; Ueda, Atsushi ^[1]; Hirayama, Aki ^[1]; Koyama, Akio ^[1]

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1. Pathophysiology of Renal Diseases, Medical Sciences for Control of Pathological Processes, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki (Japan)
2. Yamagata Promotional Organization for Industrial Technology, Yamagata (Japan)
3. New Industry Creation Hatchery Center, University of Tohoku, Miyagi (Japan)

Reactive oxygen species play an important role in adriamycin (ADR) nephropathy. We showed by in vivo electron paramagnetic resonance (EPR) that renal reducing ability (RRA) declined on the 7th day after ADR administration. Proteinuria appeared after the decline in RRA. The aim of this study was to prove by in vivo EPR whether the decline in RRA is altered by scavengers such as dimethyl sulfoxide (DMSO) and dimethylthiourea (DMTU) and that it is this change which is responsible for the proteinuria in ADR nephropathy. By showing that DMSO and DMTU ameliorate the RRA, we demonstrate that the decline in RRA is related to ADR-induced proteinuria.

• OSTI ID: 20713426
• Journal Information: Biochemical and Biophysical Research Communications, Vol. 337, Issue 1; Other Information: DOI: 10.1016/j.bbrc.2005.08.266; PII: S0006-291X(05)01952-2; Copyright (c) 2005 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved; Country of input: International Atomic Energy Agency (IAEA); ISSN 0006-291X
• Country of Publication: United States
• Language: English

Related Subjects

60 APPLIED LIFE SCIENCES
ANTIOXIDANTS
DMSO
DOXORUBICIN
ELECTRON SPIN RESONANCE
IN VIVO
OXYGEN
RADIORECEPTOR ASSAY