Evaluation of the annual killifish Nothobranchius guentheri as a tool for rapid acute toxicity screening

Journal Article · Fri Oct 01 00:00:00 EDT 1999 · Environmental Toxicology and Chemistry

DOI:https://doi.org/10.1897/1551-5028(1999)018<2258:EOTAKN>2.3.CO;2· OSTI ID:20006598

Shedd, T R; Widder, M W; Toussaint, M W; Sunkel, M C; Hull, E

This study evaluated the use of Nothobranchius guentheri as a novel organism for rapid acute toxicity screening. A major advantage of the species is that there is no need to maintain a continuous culture to have organisms immediately available for testing. Rather, the embryos are viable under long-term storage conditions and can be hatched within a few hours. The tests require only 24 h with standard laboratory equipment. Sensitivity levels for 11 representative toxicants were comparable to those reported for five of the standard US Environmental Protection Agency test species requiring continuous culture.

• Research Organization: Army Center for Environmental Health Research, Fort Detrick, MD (US)
• OSTI ID: 20006598
• Journal Information: Environmental Toxicology and Chemistry, Vol. 18, Issue 10; Other Information: PBD: Oct 1999; ISSN 0730-7268
• Country of Publication: United States
• Language: English

Related Subjects

54 ENVIRONMENTAL SCIENCES
56 BIOLOGY AND MEDICINE
APPLIED STUDIES
WATER POLLUTION
BIOLOGICAL INDICATORS
FISHES
BIOASSAY
TOXIC MATERIALS
EMBRYOS